Promiscuous HER-2/Neu CD4 T cell epitopes
AssigneeDendreon Corporation
InventorsJami B. Wollan, Lori A. Jones
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Abstract
The present invention relates to the discovery of novel T cell epitopes of the human HER-2/Neu protein that is promiscuous for at least 25 different HLA-DR alleles. The invention also relates to compositions that contain one of the novel epitopes or a fusion peptide of such a epitope and a heterologous polypeptide. Further disclosed herein is the use of the epitopes or their fusion peptides, and compositions containing the epitopes or their fusion peptides.
Claims10
A method for inducing in a patient a T cell immune response specific to a HER-2/Neu protein, the method comprising the step of administering an effective amount of a composition comprising a peptide consisting of the amino acid sequence of SEQ ID NO:
- 2, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 31 to the patient.
The method of claim, wherein the heterologous polypeptide is a granulocyte-macrophage colony-stimulating factor (GM-CSF).
Dependencies are inferred from the claim text.