Promiscuous PAP CD4 T cell epitopes
AssigneeDendreon Corporation
InventorsJami B. Wollan, Lori A. Jones
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Abstract
The present invention relates to the discovery of novel T cell epitopes of the human prostatic acid phosphatase (PAP) protein that is promiscuous for at least 15 different HLA-DR alleles. The invention also relates to compositions that contain one of the novel epitopes or a fusion peptide of such an epitope and a heterologous polypeptide. Further disclosed herein is the use of the epitopes or their fusion peptides, and compositions containing the epitopes or their fusion peptides.
Claims10
An isolated nucleic acid encoding a fusion polypeptide consisting of (1) a peptide consisting of 15 to 18 amino acids and comprising the amino acid sequence of SEQ ID NO:1, fused to (2) a heterologous peptide via a peptide bond.
Dependencies are inferred from the claim text.