Compounds for use in the treatment of cancer
AssigneePledpharma AB
InventorsJan Olof G Karlsson, Tino Kurz, Rolf Andersson
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Abstract
Pharmaceutical compositions comprise a first compound of Formula I or a physiologically acceptable salt thereof, and a cyto-protective amount of a manganese chelate of N,N′-dipyridoxyl ethylenediamine-N,N′-diacetic acid (MnPLED): wherein R1, R2, R3, R4 and X are defined in the specification.
Claims16
A pharmaceutical composition comprising a first compound of Formula I or a physiologically acceptable salt thereof, and a cyto-protective amount of a manganese chelate of N,N′-dipyridoxyl ethylenediamine-N,N′-diacetic acid (MnPLED):
- wherein
- X is CH or N,
- each R1 independently is hydrogen or —CH2COR5;
- R5 is hydroxy, optionally hydroxylated alkoxy, amino or alkylamido;
- each R2 independently is a group ZYR6;
- Z is a bond, CO, or a C1-3 alkylene or oxoalkylene group optionally substituted by a group R7;
- Y is a bond, an oxygen atom or a group NR6;
- R6 is a hydrogen atom, COOR8, an alkyl, alkenyl, cycloalkyl, aryl or aralkyl group optionally substituted by one or more groups selected from COOR8, CONR82, NR82, OR8, ═NR8, ═O, OP(O)(OR8)R7 and OSO3M;
- R7 is hydroxy, an optionally hydroxylated, optionally alkoxylated alkyl or aminoalkyl group;
- R8 is a hydrogen atom or an optionally hydroxylated, optionally alkoxylated alkyl group;
- M is a hydrogen atom or one equivalent of a physiologically tolerable cation;
- R3 is a C1-8 alkylene group, a 1,2-cykloalkylene group, or a 1,2-arylene group, optionally substituted with R7;
- and
- each R4 independently is hydrogen or C1-3 alkyl.
A kit comprising a preparation of a first active ingredient of Formula I, a preparation of a manganese chelate of N,N′-dipyridoxyl ethylenediamine-N,N′-diacetic acid (MnPLED), and optionally instructions for the simultaneous, sequential or separate administration of the preparations to a patient in need thereof:
- or a physiologically acceptable salt thereof, wherein
- X is CH or N,
- each R1 independently is hydrogen or —CH2COR5;
- R5 is hydroxy, optionally hydroxylated alkoxy, amino or alkylamido;
- each R2 independently is a group ZYR6;
- Z is a bond, CO, or a C1-3 alkylene or oxoalkylene group optionally substituted by a group R7;
- Y is a bond, an oxygen atom or a group NR6;
- R6 is a hydrogen atom, COOR8, an alkyl, alkenyl, cycloalkyl, aryl or aralkyl group optionally substituted by one or more groups selected from COOR8, CONR82, NR82, OR8, ═NR8, ═O, OP(O)(OR8)R7 and OSO3M;
- R7 is hydroxy, an optionally hydroxylated, optionally alkoxylated alkyl or aminoalkyl group;
- R8 is a hydrogen atom or an optionally hydroxylated, optionally alkoxylated alkyl group;
- M is a hydrogen atom or one equivalent of a physiologically tolerable cation;
- R3 is a C1-8 alkylene group, a 1,2-cykloalkylene group, or a 1,2-arylene group, optionally substituted with R7;
- and
- each R4 independently is hydrogen or C1-3 alkyl.
Dependencies are inferred from the claim text.