Synthetic method for montelukast sodium intermediate
AssigneeShandong New Time Pharmaceutical Co., Ltd.
InventorsZhiquan Zhao, Haixin Wang, Zengxue Wang
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Abstract
A synthesis method for preparing Montelukast sodium intermediate 2-(2-(3-(2-(7-chloro-2-quinolyl)vinyl)phenyl-3-oxopropyl)phenyl) propanol is provided. In this method, the target compound is prepared by condensing the starting materials 7-chloroquinaldine and 3-cyanobenzaldehyde, and then reacting the resultant product with 2-(2-ortho-(2-haloethyl)-phenylpropyl)tetrahydropyrane ether. The present invention can easily obtain start materials and is applicable for mass production.
Claims20
A synthesis method for preparing Montelukast sodium intermediate, 2-(2-(3-(2-(7-chloro-2-quinolyl)vinyl)phenyl-3-oxopropyl)phenyl) propanol, as shown in the following formula 1, said method comprising the following steps of:
- (f) Reacting the compound of formula 9 with the compound of formula 4 under the existence of metal magnesium and an inert solvent, to generate the target product of formula 1, 2-(2-(3-(2-(7-chloro-2-quinolyl)vinyl)phenyl-3-oxopropyl)phenyl) propanol, through the following reaction:
Dependencies are inferred from the claim text.