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US 8,569,480 B2Granted
Hydroxyethylstarch
AssigneeB. Braun Melsungen AG
InventorsMichael Boll, Andreas Fisch, Donat R. Spahn
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AssigneeB. Braun Melsungen AG
InventorsMichael Boll, Andreas Fisch, Donat R. Spahn
Estimating the term…
Described are a hydroxyethylstarch, a process for the preparation thereof, a pharmaceutical formulation containing such a hydroxyethylstarch, and the use of the pharmaceutical formulation for the preparation of a volume replacement, a plasma replacement or a plasma volume expander, as well as the use of the pharmaceutical formulation for maintaining normovolemia and/or for improving the macro- and microcirculation and/or for improving the nutritive oxygen supply and/or for stabilizing hemodynamics and/or for improving the volume efficiency and/or for reducing the plasma viscosity and/or for increasing anemia tolerance and/or for hemodilution, especially for therapeutic hemodilution in disturbed blood supply and arterial, especially peripheral arterial, occlusive diseases.
A hydroxyethylstarch having an average molecular weight, Mw, of from above 600,000 to 1,500,000, characterized by having a molar substitution MS of from 0.25 to 0.5 and a C2/C6 ratio of from 2 to below 8, wherein the hydroxyethylstarch is at least sterile filtered or heat sterilized for use as a volume replacement or plasma expander.
A process for preparing a hydroxyethylstarch for use as a volume replacement or plasma expander comprising the steps:
A method of treating a patient in need of maintaining normovolemia, improving macro- and microcirculation, improving nutritive oxygen supply, stabilizing hemodynamics, improving volume efficiency, reducing plasma viscosity, increasing anemia tolerance, requiring hemodilution, or a combination thereof, the method comprising:
Dependencies are inferred from the claim text.