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US 8,569,459 B2Granted
Targeted binding agents directed to sonic hedgehog homolog and uses thereof
AssigneeMedImmune, LLC
InventorsDavid Jenkins, Neil Michaud, Naomi Laing, Jaspal Singh Kang
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Abstract
The invention relates to targeted binding agents against human sonic hedgehog homolog (Shh) and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to Shh. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of Shh and as diagnostics.
Claims20
An isolated nucleic acid molecule encoding an antibody or binding fragment thereof that specifically binds to sonic Hedgehog Homolog (Shh), wherein the antibody or fragment thereof comprises:
- (a) a variable heavy (VH) chain complementarity determining region (CDR) 1, CDR2 and CDR3 of SEQ ID NO:
- 50;
- and
- (b) a variable light (VL) chain CDR1, CDR2 and CDR3 of SEQ ID NO:
- 54.
2 more elements
Dependencies are inferred from the claim text.