Affinity material
AssigneeBiotage AB
InventorsAnthony Rees, Börje Sellergren, Ecevit Yilmaz, Thomas Schrader
Life of this patent
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Abstract
The present application relates to an affinity material useful in antibody purification.
Claims12
A molecularly imprinted polymer, wherein said polymer is cross-linked and comprises one or more sites selectively binding one or more antibodies, wherein said one or more sites are complementary to one or more template molecule selected from one or more peptides comprising an amino acid sequence corresponding to a subsequence of a domain of one or more antibodies wherein said amino acid sequence is selected from the group consisting of QKSLSLSPGK, QKSLSLSPG, QKSLSLSP, QKSLSLS, QKSLSL, QKSLS, QKSL, QKS, QK KSLSLSPGK, SLSLSPGK, LSLSPGK, SLSPGK, LSPGK, SPGK, PGK or GK.
A molecularly imprinted polymer, obtainable by
- providing one or more monomers, template molecules, initiators and cross-linking agents;
- polymerizing said one or more monomers, templates, initiators and cross-linking agents;
- removing said templates;
- wherein said one or more template molecules is independently selected from one or more peptides comprising an amino acid sequence corresponding to a subsequence of a domain of one or more antibodies wherein said amino acid sequence is selected from the group consisting of QKSLSLSPGK, QKSLSLSPG, QKSLSLSP, QKSLSLS, QKSLSL, QKSLS, QKSL, QKS, QK KSLSLSPGK, SLSLSPGK, LSLSPGK, SLSPGK, LSPGK, SPGK, PGK or GK.
Dependencies are inferred from the claim text.