p27 protein inducer

A method of treating rheumatism or inflammation in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof:

• wherein:
• X is a heteroaryl group or R3R4NCO—;
• Y1 and Y2 are each independently —N═ or —CR11═;
• Y3 and Y4 may be the same or different, and are each —CR12═;
• A is a group represented by general formula (2) below or a group represented by general formula (3) below:
• R1 is a hydrogen atom, a halogen atom, a cyano group, a C1-6 alkyl group, a C2-7 alkenyl group, a carbamoyl group or a C2-7 alkynyl group where the C2-7 alkynyl group may optionally be substituted with a C1-4 acyl group;
• R2 is a C1-6 alkyl group optionally substituted with a halogen atom;
• R3, R4, R6, R7, R9 and R10 are each independently a hydrogen atom, a C1-6 alkoxy group, a C3-8 cycloalkyl group or a C1-6 alkyl group where the C1-6 alkyl group may optionally be substituted with a group selected from a cyano group, a halogen atom, a hydroxy group, a C1-6 alkoxy group and —NR13R14;
• the combination of R3 and R4, combination of R6 and R7, and combination of R9 and R10 may form, together with the nitrogen atom to which they are bonded, a 4- to 6-membered heterocyclic group having at least one nitrogen atom;
• R5, R8, R13 and R14 are each independently a hydrogen atom or a C1-6 alkyl group;
• R11 is a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-4 acyl group, a C1-4 acyloxy group or —NR15R16;
• R12 is a hydrogen atom, a halogen atom or a C1-6 alkyl group;
• and
• R15 and R16 are each independently a hydrogen atom or a C1-4 acyl group.