Compositions
AssigneeReckitt Benckiser Healthcare (UK) Limited
InventorAlistair Campbell
Life of this patent
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Abstract
An ingestible particulate composition comprises: a) at least one compound selected from the group consisting of 2,4-dichlorobenzyl alcohol, amylmetacresol, cetylpyridinium chloride, hexitidine, hexylresorcinol, flurbiprofen, lidocaine, benzocaine, ibuprofen, paracetamol, pectin, menthol, and benzydamine; and b) one or more bioadhesive materials. Resulting particulate compositions have excellent flow characteristics, dust suppression, organoleptic properties and stability. They are highly suitable for administration direction into a patient's mouth, and ingested to alleviate the symptoms of a sore throat.
Claims17
An ingestible particulate composition comprising:
- at least one pharmaceutically active compound selected from the group consisting of 2,4-dichlorobenzyl alcohol, amylmetacresol, cetylpyridinium chloride, hexitidine, hexylresorcinol, flurbiprofen, lidocaine, benzocaine, ibuprofen, paracetamol, pectin, menthol, and benzydamine;
- one or more bioadhesive materials present in an amount up to 10 wt %;
- sodium bicarbonate;
- and
- citric acid;
- wherein a mean particle size of the particulate composition is not greater than 1.0 mm.
A method of treating sore throat comprising:
- administering a flowable particulate composition into a mouth of a patient, the composition comprising:
- at least one pharmaceutically active compound selected from the group consisting of 2,4-dichlorobenzyl alcohol, amylmetacresol, cetylpyridinium chloride, hexitidine, hexylresorcinol, flurbiprofen, lidocaine, benzocaine, ibuprofen, paracetamol, pectin, menthol, and benzydamine;
- one or more bioadhesive materials present in an amount up to 10 wt %;
- sodium bicarbonate;
- and
- citric acid;
- wherein a mean particle size of the particulate composition is not greater than 1.0 mm.
A method of making of a particulate composition suitable for pouring into a mouth of a patient comprising forming a composition comprising:
- at least one pharmaceutically active compound selected from the group consisting of 2,4-dichlorobenzyl alcohol, amylmetacresol, cetylpyridinium chloride, hexitidine, hexylresorcinol, flurbiprofen, lidocaine, benzocaine, ibuprofen, paracetamol, pectin, menthol, and benzydamine;
- one or more bioadhesive materials present in an amount up to 10 wt %;
- sodium bicarbonate;
- and
- citric acid;
- wherein a mean particle size of the particulate composition is not greater than 1.0 mm.
A targeted outlet pack containing a single dose of an ingestible flowable particulate composition, the targeted outlet pack being adapted to deposit the composition onto a small area within the mouth, the composition comprising:
- at least one pharmaceutically active compound selected from the group consisting of 2,4-dichlorobenzyl alcohol, amylmetacresol, cetylpyridinium chloride, hexitidine, hexylresorcinol, flurbiprofen, lidocaine, benzocaine, ibuprofen, paracetamol, pectin, menthol, and benzydamine;
- one or more bioadhesive materials present in an amount up to 10 wt %;
- sodium bicarbonate;
- and
- citric acid;
- wherein a mean particle size of the particulate composition is not greater than 1.0 mm.
Dependencies are inferred from the claim text.