Imidazole based LXR modulators

A compound according to the formula,

• or a pharmaceutically acceptable salt thereof, wherein,
• L1 is —[C(R15)2]m′— or —C3-C8 cycloalkyl;
• wherein m′ is any of 1 to 3;
• and
• each R15 is independently hydrogen, halogen, (C1-C6)alkyl, or (C1-C6)haloalkyl;
• R5 is aryl, heterocyclyl, heteroaryl, —(C3-C6)cycloalkyl, —C, or —B—C, wherein
• B is —[C(R15)2]m— or —C3-C8 cycloalkyl-;
• and
• C is halogen, —C1-C6alkyl, —C1-C6haloalkyl, —SO2R11, —SR11, —SO2N(R11)2, —SO2NR11COR11, —C≡N, —C(O)OR11, —CON(R11)2, or —N(R11)2,
• wherein R5 is optionally substituted with one or more R5a, wherein
• each R5a is independently halogen, nitro, heteroaryl, heterocyclyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, (C3-C8 cycloalkyl)-C2-C6 alkenyl-, aryl, arylalkyl, aryloxy, aryloxyaryl, arylC1-6 alkoxy, C1-C6 alkyl, C1-C6 haloalkyl, SO2R11, OR11, SR11, N3, SO2R11, COR11, SO2N(R11)2, SO2NR11COR11, C≡N, C(O)OR11, CON(R11)2, CON(R11)OR11, OCON(R11)2, NR11COR11, NR11CON(R11)2, NR11COOR11, or N(R11)2, wherein
• each R5a is optionally substituted with one or more groups which independently are -halogen, —C1-C6 alkyl, aryloxy C0-6 alkylSO2R11, C0-6 alkylCOOR11, C0-6 alkoxyaryl, C1-C6 haloalkyl, —SO2R11, —OR11, —SR11, —N3, —SO2R11, —COR11, —SO2N(R11)2, —SO2NR11COR11, —C≡N, —C(O)OR11, —CON(R11)2, —CON(R11)OR11, —OCON(R11)2, —NR11COR11, —NR11CON(R11)2, —NR11COOR11, or —N(R11)2;
• R21 is hydrogen, halogen, nitro, cyano, C1-C6alkyl, or C1-C6haloalkyl;
• R2 is —H, —[C(R15)2]m—OH, —C1-C6alkyl, —C1-C6 haloalkyl, halogen, —C(O)N(R11)2, or —COOR11;
• provided that R2 and R21 are not simultaneously hydrogen;
• J and K are both phenyl;
• each R4 and R41 is independently halogen, oxo, nitro, CR11═CR11COOR11, aryloxy, aralkyloxy, aryloxyalkyl, arylC0-C6 alkylcarboxy, aryl, heteroaryl, heterocyclyl, heteroaryloxy, heterocyclyloxy, -G1, -E-G1′ or -D-E-G1, wherein
• D is —O—;
• E is —[C(R15)2]m— or —C3-C8cycloalkyl;
• and
• G1 is —C1-C6alkyl, —C1-C6haloalkyl, —COR11, —COOR11, —CON(R11)2, —C≡N, —OR11, —OCON(R11)2, —OCOOR11, —N3, —NR11COR11, —NR11SO2R11, —N(R11)2, —NR11COOR11, —SO2R11, —SO2NR11COR11, —SO2N(R11)2, —SOR11, or —SR11;
• wherein each R4 is optionally substituted with one or more R4a,
• wherein each R4a is independently halogen, aryloxy, aralkyloxy, aryloxyalkyl, C1-C6 alkoxyaryl, arylC0-C6 alkylcarboxy, -G′, -E′-G′, or -D′-E′-G′, wherein
• D′ is —O—;
• E′ is —[C(R15)2]m— or —C3-C8cycloalkyl-;
• and
• G′ is —H, -halogen, —COR11, —COOR11, —C≡N, OR11, —NR11SO2R11, —SO2R11, —SO2N(R11)2, or —SR11;
• L2 is a bond or —[C(R15)2]m—V2—[C(R15)2]n—, wherein
• V2 is independently —C(R11)2—, —C(R11)2C(R11)2—, —C(R11)═C(R11)—, —C(R11)2O—, —C(R11)2NR11—, —C≡C—, —O—, —S—, —SO2—, —N(R10)CO—, —N(R10)CO2—, —CON(R10)—, —CON(R11)—, —CON(R11)O—, —CO—, —CS—, —CO2—, —OC(═O)—, —OC(═O)N(R10)—, —N(R10)SO2—, —SO2N(R10)—, —NR10CONR10—, —NR10CSNR10—, C3-C6cycloalkyl-, or C3-C6cyclohaloalkyl, or V2 is C2-6 alidiyl,
• wherein alidiyl chain is optionally interrupted by —C(R11)2—, —C(R11)2C(R11)2—, —C(R11)═C(R11)—, —C(R11)2O—, —C(R11)2NR11—, —C(R11)2NR11—, —C≡C—, —O—, —S—, —N(R10)CO—, —N(R10)CO2—, —CON(R10)—, —CON(R11)—, —CON(R11)O—, —CO—, —CO2—, —OC(═O)—, —OC(═O)N(R10)—, —SO2—, —N(R10)SO2— or —SO2N(R10)—;
• or V2 is aryl, heteroaryl, or heterocyclyl, each of which is optionally substituted with one or more R9, wherein
• each R9 is independently halogen, C1-C6 haloalkyl, C1-C6 alkyl, C1-C6 alkyloxy, C0-C6 alkyl or C1-C6 alkylCOOR11;
• each m is 0, 1, 2, 3, 4, 5, or 6;
• q is 1, 2, 3, 4, or 5,
• q′ is 0, 1, 2, 3, or 4,
• each R10 is independently —R11, —C(═O)R11, —CO2R11, or —SO2R11;
• each R11 is independently -hydrogen, —C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, (C3-C8 cycloalkyl)-C2-C6 alkenyl-, —C1-C6 haloalkyl, —N(R12)2, aryl, —(C1-C6)alkyl-aryl, heteroaryl, —(C1-C6)alkyl-heteroaryl, heterocyclyl, or —(C1-C6)alkyl-heterocyclyl,
• wherein any of R11 is optionally substituted with one or more radicals of R12;
• each R12 is independently halogen, C1-C6haloalkyl, C1-C6 alkyl, C1-C6 alkoxy, (C0-C6 alkyl)C═O(OR13);
• C0-C6 alkylOR13, C0-C6 alkylCOR13, C0-C6 alkylSO2R13, C0-C6 alkylCON(R13)2, C0-C6 alkylCONR13OR13, C0-C6 alkylSO2N(R13)2, C0-C6 alkylSR13, C0-C6 haloalkylOR13, aryloxy, aralkyloxy, aryloxyalkyl, C0-6alkoxyaryl, arylC0-6 alkylcarboxy, —C0-C6 alkylN(R13)2, —NR13SO2R13, or —OC0-6 alkylCOOR13;
• and
• each R13 is independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, or (C3-C8 cycloalkyl)-C2-C6 alkenyl.

A compound according to one of the following formulas,

• or a pharmaceutically acceptable salt thereof, wherein,
• R1 is -L1-R5, wherein
• L1 is a bond, —[C(R15)2]m—, or —C3-C8 cycloalkyl-;
• and
• R5 is phenyl or pyridyl, each optionally substituted with one or two R5a, wherein
• each R5a is independently -halogen, —C1-C6 alkoxy, —C1-C6 alkyl, or —C1-C6haloalkyl;
• R2, R21, and R3 are each independently —H, —[C(R15)2]m—OH, —C1-C6 alkyl, —C1-C6 haloalkyl, halogen, —C(O)N(R11)2, or —COOR11;
• provided that R2 and R21 are not simultaneously hydrogen;
• G is a group of the formula,
• wherein
• L2 is a bond;
• J is phenyl, pyridyl, or thienyl;
• K is phenyl or pyridyl;
• q is 0, 1, 2, 3, 4, or 5, provided that q is 0 if and only if K is not phenyl;
• q′ is 0, 1, 2, 3, or 4,
• each R41 is -halogen, —C1-C6 alkyl, or C1-C6 -haloalkyl;
• and
• each R4 is -halogen, —[C(R15)2]m—OH, —SO2R11, —SO2N(R11)2, —C(O)N(R11)2, —COOR11, —C1-C6 alkyl, or —C1-C6 haloalkyl;
• each m is 0, 1, 2, 3, 4, 5, or 6;
• each R15 is independently hydrogen, halogen, (C1-C6)alkyl, (C3-C6)cycloalkyl, or (C1-C6)haloalkyl;
• and
• each R11 is independently -hydrogen, —C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, (C3-C8 cycloalkyl)-C2-C6 alkenyl-, —C1-C6 haloalkyl, —N(R12)2, heterocyclyl, or —(C1-C6)alkyl-heterocyclyl, wherein any of R11 is optionally substituted with one or more radicals of R12;
• each R12 is independently halogen, C1-C6haloalkyl, C1-C6 alkyl, C1-C6 alkoxy, (C0-C6 alkyl)C═O(OR13);
• C0-C6 alkylOR13, C0-C6 alkylCOR13, C0-C6 alkylSO2R13, C0-C6 alkylCON(R13)2, C0-C6 alkylCONR13OR13, C0-C6 alkylSO2N(R13)2, C0-C6 alkylSR13, C0-C6 haloalkylOR13, aryloxy, aralkyloxy, aryloxyalkyl, C0-6 alkoxyaryl, arylC0-6 alkylcarboxy, -C0-C6 alkylN(R13)2, —NR13SO2 R13, or —OC0-6 alkylCOOR13;
• and
• each R13 is independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, or (C3-C8 cycloalkyl)-C2-C6 alkenyl-.

A compound according to the formula,

• or a pharmaceutically acceptable salt thereof, wherein
• L1 is —[C(R15)2]m— or —C3-C8 cycloalkyl;
• wherein m' is 1 or 2;
• and
• R5 is heteroaryl optionally substituted with one or more R5a, wherein
• each R5a is independently halogen, nitro, heteroaryl, heterocyclyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, (C3-C8 cycloalkyl)-C2-C6 alkenyl-, aryl, arylalkyl, aryloxy, aryloxyaryl, arylC1-6 alkoxy, C1-C6 alkyl, C1-C6 haloalkyl, SO2R11, OR11, SR11, N3, SO2R11, COR11, SO2N(R11)2, SO2NR11COR11, C≡N, C(O)OR11, CON(R11)2, CON(R11)OR11 , OCON(R11)2, NR11COR11, NR11CON(R11)2, NR11COOR11, or N(R11)2, wherein
• each R5a is optionally substituted with one or more groups which independently are -halogen, —C1-C6 alkyl, aryloxy C0-6 alkylSO2R11, C0-6 alkylCOOR11, C0-6 alkoxyaryl, C1-C6 haloalkyl, —SO2R11, —OR11, —SR11, —N3, —SO2R11, —COR11, —SO2N(R11)2, —SO2NR11COR11, —C≡N, —C(O)OR11, —CON(R11)2, —CON(R11)OR11, —OCON(R11)2, —NR11COR11, —NR11CON(R11)2, —NR11COOR11, or —N(R11)2;
• R21 is hydrogen, halogen, nitro, cyano, C1-C6alkyl, or C1-C6haloalkyl;
• R2 is —H, —[C(R15)2]m—OH, —C1-C6 alkyl, —C1-C6 haloalkyl, halogen, —C(O)N(R11)2, or —COOR11;
• provided that R2 and R21 are not simultaneously hydrogen;
• each m is 0, 1, 2, 3, 4, 5, or 6;
• q is 1, 2, 3, 4, or 5,
• q′ is 0, 1, 2, 3, or 4, and
• each R4 and R41 is independently halogen, oxo, nitro, CR11═CR11COOR11, aryloxy, aralkyloxy, aryloxyalkyl, arylC0-C6 alkylcarboxy, aryl, heteroaryl, heterocyclyl, heteroaryloxy, heterocyclyloxy, -G1, -E-G1′ or -D-E-G1, wherein
• D is —O—;
• E is —[C(R15)2]m— or —C3-C8cycloalkyl;
• and
• G1 is —C1-C6alkyl, —C1-C6haloalkyl, —COR11, —COOR11, —CON(R11)2, —C≡N, —OR11, —OCON(R11)2, —OCOOR 11, —N3, —NR11COR11, —NR11SO2R11, —N(R11)2, —NR11COOR11, —SO2R11, —SO2NR11COR11, —SO2N(R11)2, —SOR11, or —SR11;
• wherein each R4 is optionally substituted with one or more R4a,
• wherein each R4a is independently halogen, aryloxy, aralkyloxy, aryloxyalkyl, C1-C6 alkoxyaryl, arylC0-C6 alkylcarboxy, -G′, -E′-G′, or-D′-E′-G′, wherein
• D′ is —O—;
• E′ is —[C(R15)2]M— or —C3-C8cycloalkyl-;
• and
• G′ is —H, -halogen, —COR11, —COOR11, —C≡N, OR11, —NR11SO2R11, —SO2R11, —SO2N(R11)2, or —SR11;
• each R11 is independently -hydrogen, —C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, (C3-C8 cycloalkyl)-C2-C6 alkenyl-, -C1-C6 haloalkyl, —N(R12)2, aryl, -(C1-C6)alkyl-aryl, heteroaryl, —(C1-C6)alkyl-heteroaryl, heterocyclyl, or —(C1-C6)alkyl-heterocyclyl,
• wherein any of R11 is optionally substituted with one or more radicals of R12;
• each R12 is independently halogen, C1-C6haloalkyl, C1-C6 alkyl, C1-C6 alkoxy, (C0-C6 alkyl)C═O(OR13);
• C0-C6 alkylOR13, C0-C6 alkylCOR13, C0-C6 alkylSO2R13, C0-C6 alkylCON(R13)2, C0-C6 alkylCONR13OR13, C0-C6 alkylSO2N(R13)2, C0-C6 alkylSR13, C0-C6 haloalkylOR13, aryloxy, aralkyloxy, aryloxyalkyl, C0-6alkoxyaryl, arylC0-6 alkylcarboxy, —C0-C6 alkylN(R13)2, —NR13SO2 R13, or —OC0-6 alkylCOOR13;
• each R13 is independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, or (C3-C8 cycloalkyl)-C2-C6 alkenyl-;
• and each R15 is independently H, halogen, or (C1-C6)alkyl.

A compound according to one of the following formulas,

• or a pharmaceutically acceptable salt thereof, wherein,
• R1 is -L1-R5, wherein
• L1 is a bond, —C3-C8 cycloalkyl- or L5, wherein
• each L5 is independently —[C(R15)2]m—, wherein
• m is 0, 1, 2, or 3;
• and
• each R15 is independently hydrogen, halogen, (C1-C6)alkyl, or (C1-C6)haloalkyl;
• and
• R5 is aryl, heterocyclyl, heteroaryl, —C, or -B-C, wherein
• B is —[C(R15)2]m—, —C3-C6cycloalkyl-;
• and
• C is —C1-C6alkyl or —C1-C6haloalkyl;
• wherein R5 is optionally substituted with one or more R5a, wherein
• each R5a is independently halogen, nitro, heteroaryl, heterocyclyl, C2-C6 alkenyl, C2-C6 alkynyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, (C3-C8 cycloalkyl)-C2-C6 alkenyl-, aryl, arylalkyl, aryloxy, aryloxyaryl, arylC1-6 alkoxy, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6cycloalkyl, SO2R11, OR11, SR11, N3, SO2R11, COR11, SO2N(R11)2, SO2NR11COR11, C≡N, C(O)OR11, CON(R11)2, CON(R11)OR11, OCON(R11)2, NR11COR11, NR11CON(R11)2, NR11COOR11, or N(R11)2, wherein
• each R5a is optionally substituted with one or more groups which independently are -halogen, —C1-C6 alkyl, aryloxy, C0-6 alkylSO2R11, C0-6 alkylCOOR11, C0-6 alkoxyaryl, —C1-C6 haloalkyl, —SO2R11, OR11, —SR11, —N3, —SO2R11, —COR11, —SO2N(R11)2, —SO2NR11COR11, —C≡N, —C(O)O R11, —CON(R11)2, —CON(R11)OR11, —OCON(R11)2, —NR11COR11, —NR11CON(R11)2, —NR11COOR11, or —N(R11)2;
• R2 is —H, —[C(R15)2]m—OH, —C1-C6alkyl, —C1-C6 haloalkyl, halogen, —C(O)N(R11)2, or —COOR11;
• R21 is hydrogen, halogen, C1-C6 alkyl, or C1-C6 haloalkyl;
• and
• provided that R2 and R21 are not simultaneously hydrogen;
• G is a group of the formula,
• wherein
• J is aryl or heteroaryl;
• K is aryl or heteroaryl;
• each R4 and R41 is independently halogen, heteroaryl, heterocyclyl, -G1, -E- G1, or -D-E- G1,
• wherein
• D is —O—;
• E is —[C(R15)2]m— or —C3-C6cycloalkyl;
• and
• G1 is —C1-C6alkyl, —C1-C6haloalkyl, —COR11, —COOR11, —CON(R11)2, —C≡N, —OR11, —SOR11, —SO2R11, —SO2N(R11)2, or —SR11,
• L2 is a bond;
• q is 1, 2, or 3, and
• q′ is 0, 1, 2 or 3,
• each R11 is independently -hydrogen, —C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, (C3-C8 cycloalkyl)-C2-C6 alkenyl-, —C3-C8 cycloalkyl, —(C1-C6)alkyl-(C3-C8)cycloalkyl, —C1-C6 haloalkyl, —N(R12)2, aryl, —(C1-C6)alkyl-aryl, heteroaryl, —(C1-C6)alkyl-heteroaryl, heterocyclyl, or —(C1-C6)alkyl-heterocyclyl, wherein any of R11 is optionally substituted with one or more radicals of R12;
• each R12 is independently halogen, OR13, N(R13)2, C1-C6haloalkyl, C1-C6 alkyl, C1-C6 alkoxy, C0-C6 alkylOR13, C0-C6 alkylCOR13, C0-C6 alkylSO2R13, C0-C6 alkylCON(R13)2, C0-C6 alkylCONR13OR13, C0-C6 alkylSO2N(R13)2, C0-C6 alkylSR13, C0-C6 haloalkylOR13, aryloxy, aralkyloxy, aryloxyalkyl, C0-6alkoxyaryl, arylC0-6 alkylcarboxy, C0-C6 alkyl, —NR13SO2 R13, or —OC0-6 alkylCOOR13;
• each R13 is independently hydrogen C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (C3-C8 cycloalkyl) C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, or (C3-C8 cycloalkyl)-C2-C6 alkenyl-.

A compound which is one of the species selected from the group consisting of:

• Cpd #
• Structure
• Name
• 1
• 2-(2-(2-fluorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 2
• 2-(1-(3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)benzyl)- 1H-imidazol-4- yl)propan-2-ol;
• 3
• 2-(2-(2-chlorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 4
• 2-(2-(2-chlorobenzyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 5
• 2-(2-(2-chlorobenzyl)- 1-(4′-(hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 6
• 2-(2-(2,6- dichlorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 7
• 2-(2-(2,6- dichlorobenzyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 8
• 2-(2-(2,6- dichlorobenzyl)-1-(3′- (ethylsulfonyl)-4′- (hydroxymethyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 9
• 2-(2-(2-chloro-6- fluorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 10
• 2-(2-(2-chloro-6- fluorobenzyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 11
• 2-(2-(2,3- dichlorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 12
• 2-(2-(2,3- dichlorobenzyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 13
• 3-(2-(2-chlorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)pentan-3-ol;
• 14
• 3-(2-(2-chlorobenzyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)pentan-3-ol;
• 15
• 3-(2-(2-chlorobenzyl)- 1-(4′-(hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)pentan-3-ol;
• 16
• 2-(2-(5-chloro-2- (trifluoromethyl)benzyl)- 1-(3′-(methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 17
• 2-(2-(5-chloro-2- (trifluoromethyl)benzyl)- 1-(3′-(ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 18
• 2-(2-(5-chloro-2- (trifluoromethyl)benzyl)- 1-(4′-(hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 19
• 2-(2-(2-(2- chlorophenyl)propan-2- yl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 20
• 2-(2-(2-(2- chlorophenyl)propan-2- yl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 21
• 2-(2-(2-(2,3- dichlorophenyl)propan- 2-yl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 22
• 2-(2-(2-(2,3- dichlorophenyl)propan- 2-yl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 23
• 2-(2-(2,3- dichlorobenzyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 24
• 2-(2-(2,3- dichlorobenzyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
• 25
• 2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,3- dichlorobenzyl)-1H- imidazol-4-yl)propan-2-ol;
• 26
• 2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,3- dichlorobenzyl)-1H- imidazol-4-yl)propan-2-ol;
• 27
• 2-(2-(2- chlorophenethyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 28
• 2-(2-(2- chlorophenethyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 29
• 2-(2-(2- chlorophenethyl)-1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 30
• 2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(naphthalen- 1-yl)-1H-imidazol-4- yl)propan-2-ol;
• 31
• 2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(naphthalen-1- yl)-1H-imidazol-4- yl)propan-2-ol;
• 32
• 2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(naphthalen- 1-yl)-1H-imidazol-4- yl)propan-2-ol;
• 33
• 2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(isoquinolin- 1-yl)-1H-imidazol-4- yl)propan-2-ol;
• 34
• 2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(isoquinolin-1- yl)-1H-imidazol-4- yl)propan-2-ol;
• 35
• 2-(2-(isoquinolin-5-yl)- 1-(3-methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 36
• 2-(1-(3′-(ethylsulfonyl)- 3-methylbiphenyl-4-yl)- 2-(isoquinolin-5-yl)- 1H-imidazol-4- yl)propan-2-ol;
• 37
• 2-(1-(3′- (methylsulfonyl)biphenyl- 4-yl)-2-(4- (trifluoromethyl)pyridin- 3-yl)-1H-imidazol-4- yl)propan-2-ol;
• 38
• 2-(1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(4- (trifluoromethyl)pyridin- 3-yl)-1H-imidazol-4- yl)propan-2-ol;
• 39
• 2-(1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(4- (trifluoromethyl)pyridin- 3-yl)-1H-imidazol-4- yl)propan-2-ol;
• 40
• 2-(1-(3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- morpholinoethyl)-1H- imidazol-4-yl)propan-2-ol;
• 41
• 2-(1-(3-methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(thiophen-2- yl)-1H-imidazol-4- yl)propan-2-ol;
• 42
• 2-(2-(1,5-dimethyl-1H- pyrrol-2-yl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 43
• 2-(2-(1,5-dimethyl-1H- pyrrol-2-yl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 44
• 2-(1-(2,6- dichlorophenyl)-2-(5-(3- (methylsulfonyl)phen- yl)thiophen-2-yl)-1H- imidazol-4-yl)propan-2-ol;
• 45
• 2-(1-(2,6- dichlorophenyl)-2-(5-(3- (ethylsulfonyl)phen- yl)thiophen-2-yl)-1H- imidazol-4-yl)propan-2-ol;
• 46
• 1-(2,5-dichlorophenyl)- 2-{5-[3- (methylsulfonyl)phen- yl]-2-thienyl}-4- (trifluoromethyl)-1H- imidazole;
• 47
• 1-(2-chlorophenyl)-2- {5-[3- (methylsulfonyl)phenyl]- 2-thienyl}-4- (trifluoromethyl)-1H- imidazole;
• 48
• methyl (4-{5-[1-(2- chlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}-3- methylphenyl)acetate;
• 49
• 5-{5-[1-(2,5- dichlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}-2-(ethylthio)-3- methylpyridine;
• 50
• 5-{5-[1-(2,5- dichlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}-2- (ethylsulfonyl)-3- methylpyridine;
• 51
• 5-{5-[1-(2,5- dichlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}-3-methyl-2- (methylsulfonyl)pyridine;
• 52
• 4-(5-{5-[1-(2,5- dichlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}pyridin-2- yl)morpholine;
• 53
• 1,1-dimethylethyl 4-(5- {5-[1-(2,5- dichlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}pyridin-2- yl)piperazine-1- carboxylate;
• 54
• 1-(5-{5-[1-(2,5- dichlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}pyridin-2- yl)piperazine;
• 55
• 5-{5-[1-(2- chlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}-2-(ethylthio)-3- methylpyridine;
• 56
• 5-{5-[1-(2- chlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}-3-methyl-2- (methylsulfonyl)pyridine;
• 57
• 5-{5-[1-(2- chlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}-2- (ethylsulfonyl)-3- methylpyridine;
• 58
• 2-(1-(2,6- dichlorophenyl)-2-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
• 59
• 2-(1-(2-isopropyl-6- methylphenyl)-2-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 60
• 2-(2-(3′-(ethylsulfonyl)- 3-methylbiphenyl-4-yl)- 1-(2-isopropyl-6- methylphenyl)-1H- imidazol-4-yl)propan-2-ol;
• 61
• 2-(1-(2- isopropylphenyl)-2-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 62
• 2-(2-(3′-(ethylsulfonyl)- 3-methylbiphenyl-4-yl)- 1-(2-isopropylphenyl)- 1H-imidazol-4- yl)propan-2-ol;
• 63
• 2-(1-(2,6- dichlorophenyl)-2-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 64
• 2-(1-(2,6- dichlorophenyl)-2-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 65
• 2-(2-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-1-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
• 66
• 2-(2-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-1-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
• 67
• 1,1,1-trifluoro-2-(1-(3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
• 68
• ethyl 1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazole-4-carboxylate;
• 72
• 3-(2-(2,3- dichlorophenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)pentan-3-ol;
• 73
• 3-(2-(2,3- dichlorophenyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)pentan-3-ol;
• 74
• 3-(2-(2,6- dichlorophenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)pentan-3-ol;
• 80
• N-benzyl-3′-chloro-4′- (2-(2-chloro-6- fluorophenyl)-4-(2- hydroxypropan-2-yl)- 1H-imidazol-1-yl)-3- (methylsulfonyl)biphenyl- 4-carboxamide;
• 81
• 3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl)- N-ethyl-3- (methylsulfonyl)biphenyl- 4-carboxamide;
• 82
• 2-(2,6-dichlorophenyl)- N-ethyl-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazole- 4-carboxamide;
• 83
• (2-(2,6- dichlorophenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)(4-methylpiperazin- 1-yl)methanone;
• 84
• 2-(2,6-dichlorophenyl)- N-(2-hydroxyethyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazole- 4-carboxamide;
• 85
• 2-(2,6-dichlorophenyl)- 1-(3-methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-N-(2,2,2- trifluoroethyl)-1H- imidazole-4- carboxamide;
• 86
• 2-(2,6-dichlorophenyl)- N,N-diethyl-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazole- 4-carboxamide
• 87
• 2-(2,6-dichlorophenyl)- 1-(3′- (methylsulfonyl)biphenyl- 4-yl)-N-(2,2,2- trifluoroethyl)-1H- imidazole-4- carboxamide;
• 88
• 2-(2,6-dichlorophenyl)- N-(2-fluoroethyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazole- 4-carboxamide;
• 89
• 2-(2-isopropylphenyl)- 1-(3-methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-N-(2,2,2- trifluoroethyl)-1H- imidazole-4-carboxamide;
• 90
• 2-(2-(2- (dimethylamino)-6- fluorophenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 91
• 2-(2-(2,6- dichlorophenyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 92
• 2-(2-(2-chloro-6- fluorophenyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 93
• 2-(2-(2-ethylphenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 94
• 2-(2-(2- isopropylphenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 95
• 2-(2-(2-chloro-3- fluorophenyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 96
• 2-(1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2- isopropylphenyl)-1H- imidazol-4-yl)propan-2-ol;
• 97
• 2-(2-(2-chloro-6- methylphenyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 98
• 2-(2-(2,3- dichlorophenyl)-1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 99
• 2-(2-(2,6- dichlorophenyl)-1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 100
• 2-(2-(2-chloro-6- fluorophenyl)-1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 101
• 2-(2-(3-chloro-2- methylphenyl)-1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 102
• 2-(2-(2-chloro-6- methylphenyl)-1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 103
• 2-(2-(2,6- difluorophenyl)-1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 104
• 2-(2,6-dichlorophenyl)- 1-(3′-(ethylsulfonyl)-3- methylbiphenyl-4-yl)- N-(2,2,2-trifluoroethyl)- 1H-imidazole-4- carboxamide;
• 105
• 2-(2-(2,3- dichlorophenyl)-1-(4′- (2-hydroxypropan-2-yl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 106
• 2-(2-(2,6- dichlorophenyl)-1-(3′- methyl-5′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 107
• 2-(1-(2′-chloro-5′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
• 108
• 4′-(2-(2,6- dichlorophenyl)-4-(2- hydroxypropan-2-yl)- 1H-imidazol-1-yl)-N- methylbiphenyl-3- sulfonamide;
• 109
• 2-(1-(3-fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
• 110
• 2-(1-(3′-(ethylsulfonyl)- 3-fluorobiphenyl-4-yl)- 2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
• 111
• 2-(1-(2-fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
• 112
• 2-(1-(3′-(ethylsulfonyl)- 2-fluorobiphenyl-4-yl)- 2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
• 113
• 2-(2-(2,3- dichlorophenyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 114
• 2-(2-(2,3- dichlorophenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
• 115
• 2-(2-(2,6- dichlorophenyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 116
• 2-(2-(2,6- dichlorophenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
• 117
• 2-(2-(2,3- dichlorophenyl)-1-(3- fluoro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 118
• 2-(2-(3-chloro-2- methylphenyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 119
• 2-(2-(3-chloro-2- methylphenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
• 120
• 2-(2-(3-chloro-2- methylphenyl)-1-(3- fluoro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 121
• 2-(1-(3-fluoro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
• 122
• 2-(2-(2,6- dichlorophenyl)-1-(3- fluoro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 123
• 2-(2-(2-chloro-3- fluorophenyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 124
• 2-(2-(2-chloro-3- fluorophenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
• 125
• 2-(2-(2-chloro-3- fluorophenyl)-1-(3- fluoro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 126
• 2-(2-(2-chloro-6- fluorophenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
• 127
• 2-(2-(2-chloro-6- fluorophenyl)-1-(3- fluoro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 128
• 2-(2-(2-chloro-6- methylphenyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 129
• 2-(2-(2-chloro-6- methylphenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
• 130
• 2-(2-(2,6- difluorophenyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 131
• 2-(2-(2,6- difluorophenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
• 132
• 2-(2-(2,6- difluorophenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
• 133
• 2-(2-(2-chloro-6- methylphenyl)-1-(3- fluoro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 134
• 2-(2-(2-chloro-6- fluorophenyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 135
• 2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
• 136
• 2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
• 137
• 2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2- chlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
• 138
• 2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- chlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
• 139
• 2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
• 140
• 2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,3- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
• 141
• 2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,3- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
• 142
• 2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
• 143
• 2-(2-(3-chloro-2- methylphenyl)-1-(3- chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 144
• 2-(2-(3-chloro-2- methylphenyl)-1-(3- chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 145
• 2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-6- fluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
• 146
• 2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-6- fluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
• 147
• 2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-6- fluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
• 148
• 2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,3- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
• 149
• 2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
• 150
• 2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
• 151
• 2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-3- fluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
• 152
• 2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-3- fluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
• 153
• 2-(2-(2-chloro-3- fluorophenyl)-1-(3- chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 154
• 2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-6- methylphenyl)-1H- imidazol-4-yl)propan-2-ol;
• 155
• 2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-6- methylphenyl)-1H- imidazol-4-yl)propan-2-ol;
• 156
• 2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-6- methylphenyl)-1H- imidazol-4-yl)propan-2-ol;
• 157
• 2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- difluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
• 158
• 2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,6- difluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
• 159
• 2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- difluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
• 160
• 2-(2-(3-chloro-2- methylphenyl)-1-(3- chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 161
• 2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- isopropylphenyl)-1H- imidazol-4-yl)propan-2-ol;
• 162
• 2-(3′-chloro-4′-(2-(2- chlorophenyl)-4-(2- hydroxypropan-2-yl)- 1H-imidazol-1-yl)-3- (methylsulfonyl)biphenyl- 4-yl)propan-2-ol;
• 163
• 2-(1-(3-chloro-4′-(2- hydroxypropan-2-yl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
• 164
• 2-(3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl)-3- (methylsulfonyl)biphenyl- 4-yl)propan-2-ol;
• 165
• ethyl 3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl-3- (methylsulfonyl)biphenyl- 4-carboxylate;
• 166
• (3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl)-3- (methylsulfonyl)biphenyl-4- yl)(morpholino)methanone;
• 167
• 3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl)- N,N-dimethyl-3- (methylsulfonyl)biphenyl- 4-carboxamide;
• 168
• 2-(1-(3-chloro-5- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- chlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
• 169
• 2-(1-(3-chloro-3′- (ethylsulfonyl)-5- methylbiphenyl-4-yl)-2- (2-chlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
• 170
• 2-(2-(2-chlorophenyl)- 1-(3-ethyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 171
• 2-(1-(4′- (hydroxymethyl)-3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
• 172
• 2-(2-(2-chloro-6- fluorophenyl)-1-(4′- (hydroxymethyl)-3- methyl-3′- methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 173
• 2-(2-(2-chloro-3- fluorophenyl)-1-(4′- (hydroxymethyl)-3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 174
• 2-(2-(2,6- dichlorophenyl)-1-(4′- (hydroxymethyl)-3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 175
• 2-(2-(3-chloro-2- methylphenyl)-1-(4′- (hydroxymethyl)-3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 176
• 2-(2-(2,3- dichlorophenyl)-1-(4′- (hydroxymethyl)-3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 177
• 2-(2-(2-chloro-6- methylphenyl)-1-(4′- (hydroxymethyl)-3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 178
• 2-(2-(2,6- difluorophenyl)-1-(4′- (hydroxymethyl)-3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 179
• 2-(2-(2,3- dichlorophenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 180
• 2-(2-(2,3- dichlorophenyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
• 181
• 2-(2-(2,6- dichlorophenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 182
• 2-(2-(2,6- dichlorophenyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
• 183
• 2-(1-(3-methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
• 184
• 2-(1-(3′-(ethylsulfonyl)- 3-methylbiphenyl-4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
• 185
• 2-(2-(2-chloro-3- fluorophenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 186
• 2-(2-(2-chloro-3- fluorophenyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
• 187
• 2-(2-(2-chloro-6- fluorophenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 188
• 2-(2-(2-chloro-6- fluorophenyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
• 189
• 2-(2-(3-chloro-2- methylphenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 190
• 2-(2-(3-chloro-2- methylphenyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
• 191
• 2-(2-(2-chloro-6- methylphenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 192
• 2-(2-(2-chloro-6- methylphenyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
• 193
• 2-(2-(2,6- difluorophenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 194
• 2-(2-(2,6- difluorophenyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
• 195
• 2-(2-(2- isopropylphenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 196
• 2-(1-(3′-(ethylsulfonyl)- 3-methylbiphenyl-4-yl)- 2-(2-isopropylphenyl)- 1H-imidazol-4- yl)propan-2-ol;
• 197
• 2-(1-(2,6- dichlorophenyl)-2-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
• 198
• 2-{1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 199
• 2-{1-[4′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 200
• 2-{1-[3′- (ethylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 201
• 2-{1-[3′- (methylsulfonyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 202
• 2-{1-[2′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 203
• 2-{1-(2′,3′- difluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 204
• 2-(1-{4′-[(1- methylethyl)oxy]biphenyl- 4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
• 205
• 2-{1-(4′-fluoro-3′- methylbiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 206
• 2-{1-(3′-fluorobiphenyl- 4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 207
• 2-{1-(2′,4′,5′- trifluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 208
• 2-{1-[5′-fluoro-2′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 209
• 2-{1-(4′- chlorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 210
• 2-{1-(4-pyrimidin-5- ylphenyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 211
• 2-{1-[4′- (hydroxymethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 212
• 2-{1-[4′- (dimethylamino)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 213
• 2-{1-[4′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 214
• 2-{1-[4′-(1- methylethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 215
• 2-{1-[4′-chloro-2′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 216
• 2-{1-(2′,3′,4′- trifluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 217
• 2-{1-(3′,4′- difluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 218
• 2-{1-(2′-chloro-6′- fluoro-3′- methylbiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 219
• 2-{1-[5′-chloro-2′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 220
• 2-{1-[2′-fluoro-5′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 221
• 2-{1-[2′- (methylthio)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 222
• 4′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4- carboxylic acid;
• 223
• 2-{1-[4-(1,3- benzodioxol-5- yl)phenyl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 224
• 2-(1-{4-[6- (methyloxy)pyridin-3- yl]phenyl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
• 226
• 2-{1-(3′- chlorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 227
• 2-{1-[2′-fluoro-5′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 228
• ethyl 4′-{4-(1-hydroxy- 1-methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4- carboxylate;
• 229
• 2-{1-(4-{2-[(1- methylethyl)oxy]pyridin- 3-yl}phenyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 230
• 2-{1-[3′-chloro-4′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 232
• 2-{1-[2′-fluoro-3′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 233
• 4′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- carboxamide;
• 234
• 4′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1 yl}biphenyl-4- carboxamide;
• 235
• 2-(1-{4′- [(trifluoromethyl)oxy]bi- phenyl-4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
• 236
• 2-{1-[4′-fluoro-3′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 237
• 2-{1-(4′- propylbiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 238
• 2-{1-[4′-(ethyloxy)-3′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 239
• 2-(1-{2′-[(1- methylethyl)oxy]biphenyl- 4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
• 240
• 2-(1-{3′-chloro-4′-[(1- methylethyl)oxy]biphenyl- 4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
• 241
• 2-{1-[4-(1H-indol-4- yl)phenyl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 242
• 2-{1-[4′- (methylthio)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 243
• 2-{1-[3′- (hydroxymethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 244
• 2-{1-[3′- (ethyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 245
• 2-{1-(4′-ethylbiphenyl- 4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 246
• 2-{1-(2′,4′- difluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 247
• 2-{1-(3′,4′- dichlorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 248
• 2-{1-[2′-chloro-4′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 249
• 2-{1-(4-naphthalen-2- ylphenyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 250
• 2-{1-[3′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol
• 251
• 4′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3-ol;
• 252
• 2-{1-(3′,4′,5′- trifluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 253
• 1-[5-(4-{4-(1-hydroxy- 1-methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}phenyl)-2- thienyl]ethanone;
• 254
• 2-{1-(3′,5′- difluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 255
• 2-{1-(3′-chloro-4′- fluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 256
• 2-{1-[5′-methyl-2′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 257
• 2-{1-(2′,5′- difluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 258
• 2-{1-[3′- (butyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 259
• 2-{1-[5′-chloro-2′- (ethyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 260
• 2-(1-{3′- [(trifluoromethyl)oxy]bi- phenyl-4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
• 261
• 2-{1-(2′,3′,5′- trifluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 262
• 2-{1-[3′- (ethylthio)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 263
• 2-(1-{3′-[(1- methylethyl)oxy]biphenyl- 4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
• 264
• 2-{1-[4-(1-benzothien- 3-yl)phenyl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 265
• 2-{1-[4-(4- methylnaphthalen-1- yl)phenyl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 266
• 2-{1-(2′,4′- dichlorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 267
• 2-{1-[3′,4′- bis(methyloxy)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 268
• 2-{2-[2- (trifluoromethyl)phenyl]- 1-(2′,4′,5′- trimethylbiphenyl-4- yl)-1H-imidazol-4- yl}propan-2-ol;
• 269
• 4-fluoro-4′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-2-ol;
• 270
• 2-{1-[2′- (hydroxymethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 271
• 2-{1-[3′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl]propan-2-ol;
• 272
• 2-{1-(2′-chloro-6′- fluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 273
• 2-{1-[3′,5′-difluoro-2′- (methyloxy)biphenyl-4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 274
• 2-(1-{4-[2- (methyloxy)pyridin-3- yl]phenyl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
• 275
• 2-{1-[2′-methyl-5′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 276
• 2-{1-(2′-ethylbiphenyl- 4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 277
• 2-(1-{2′-methyl-4′-[(1- methylethyl)oxy]biphenyl- 4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
• 278
• 2-{1-[4′- (ethylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 279
• 2-{1-(5′-fluoro-2′- methylbiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 280
• 2-{1-[3′-chloro-4′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 281
• 2-{1-(5′-chloro-2′- methylbiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 282
• 2-{1-[2′-(ethyloxy)-5′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 283
• 2-{1-(3′-fluoro-4′- methylbiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 284
• methyl (2E)-3-(4′-{4- (1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4-yl)prop- 2-enoate;
• 285
• N-ethyl-4′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- carboxamide;
• 286
• 2-{1-[4-(2,3-dihydro-1- benzofuran-5- yl)phenyl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 287
• 2-(1-{3-[6- (methyloxy)pyridin-3- yl]phenyl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
• 288
• 3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1-yl}-N-(1- methylethyl)biphenyl- 3-sulfonamide;
• 289
• 3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4- carboxamide;
• 290
• 2-(1-{3-[2- (cyclopentyloxy)pyridin- 3-yl]phenyl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
• 291
• 2-{1-(3′- chlorobiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 292
• 2-{1-[2′-fluoro-5′- (methyloxy)biphenyl-3- yl]-2-[2 (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 293
• 3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- carboxamide;
• 294
• 2-{1-[3′,4′- bis(methyloxy)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 295
• N-(3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-2- yl)methanesulfonamide;
• 296
• 2-{1-[3′- (trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 297
• 3-fluoro-3′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4- carboxylic acid;
• 298
• 4-chloro-3′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- carboxamide;
• 299
• 2-{1-(3-{2-[(1- methylethyl)oxy]pyridin- 3-yl}phenyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 300
• N-(3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- yl)acetamide;
• 301
• 2-{1-[2′-methyl-5′- (methyloxy)biphenyl-3- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 302
• N-(3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4- yl)acetamide;
• 303
• 2-{1-(4′- chlorobiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 304
• 2-{1-[4′- (phenyloxy)biphenyl-3- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 305
• 2-{1-[5′-fluoro-2′- (methyloxy)biphenyl-3- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 306
• 2-{1-(2′,3′- dichlorobiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 307
• 2-(1-{3′- [(trifluoromethyl)oxy]bi- phenyl-3-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
• 308
• 3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- sulfonamide;
• 309
• 2-{1-[3′,5′- bis(trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 310
• 2-{1-(3′,5′- dichlorobiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 311
• 3-chloro-3′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1-yl}-N- (1-methylethyl)biphenyl- 4-carboxamide;
• 312
• N,N-diethyl-3′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- carboxamide;
• 313
• 4-chloro-3′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1-yl}-N-(1- methylethyl)biphenyl- 3-carboxamide;
• 314
• 2-{1-[3′- (methyloxy)biphenyl-3- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 315
• 3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- carboxylic acid;
• 316
• N-ethyl-3′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-l- yl}biphenyl-3- carboxamide;
• 317
• 4-chloro-N-ethyl-3′-{4- (1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- carboxamide;
• 318
• 2-{1-(2′,5′- difluorobiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 319
• 2-(1-{3′-[(1- methylethyl)oxy]biphenyl- 3-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
• 320
• 2-{1-[2′-fluoro-5′- (trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 321
• 2-{1-(3′,4′- dichlorobiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 322
• 2-{1-[3′- (ethyloxy)biphenyl-3- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 323
• 2-(1-{2′-methyl-4′-[(1- methylethyl)oxy]biphenyl- 3-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
• 324
• 2-{1-[3-(1-methyl-1H- indol-5-yl)phenyl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 325
• 2-{1-[4′-(ethyloxy)-3′- (trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 326
• 2-{1-[3′- (ethylsulfonyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 327
• 2-{1-[2′- (trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 328
• 2-{1-[3′- (hydroxymethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 329
• 2-{1-[3-(1H-indol-4- yl)phenyl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 330
• 3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4- carboxylic acid;
• 331
• 1-[5-(3-{4-(1-hydroxy- 1-methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}phenyl)-2- thienyl]ethanone;
• 332
• 2-{1-(5′-chloro-2′- methylbiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 333
• 2-(1-{4′- [(trifluoromethy)oxy]bi- phenyl-3-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
• 334
• 2-{1-[2′-chloro-4′- (trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 335
• 2-{1-(2′,5′- dichlorobiphenyl-3-yl)- 2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 336
• 2-{1-[2′-(ethyloxy)-5′- (trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 337
• 3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1-yl}-N-(1- methylethyl)biphenyl- 4-carboxamide;
• 338
• 2-{1-(2′,4′- dichlorobiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 339
• 2-{1-[4- (ethylsulfonyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 340
• 2-{1-[4′-fluoro-3′- (trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 341
• 2-{1-(3′-fluoro-4′- methylbiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 342
• N-butyl-4′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- sulfonamide;
• 343
• N-(1,1-dimethylethyl)- 4′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1-yl}-6- methylbiphenyl-3- sulfonamide;
• 344
• 4′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1-yl}-N- methylbiphenyl-3- sulfonamide;
• 345
• N-ethyl-4′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- sulfonamide;
• 346
• N-(1,1-dimethylethyl)- 4′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- sulfonamide;
• 347
• 2-{1-[2′-amino-5′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 348
• 2-{1-[3′-fluoro-5′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 349
• 2-{1-[4′-chloro-3′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 350
• 3-chloro-4′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4- carboxylic acid;
• 351
• 2-(2-[2- (trifluoromethyl)phenyl]-1-{3′- [(trifluoromethyl)thio]bi- phenyl-4-yl}-1H- imidazol-4-yl)propan-2-ol;
• 352
• 2-{1-[3′-(morpholin-4- ylsulfonyl)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 353
• 2-(1-{4-[5- (hydroxymethyl)-1,3- thiazol-2-yl]phenyl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
• 354
• 2-{1-[2′-methyl-5′- (piperidin-1- ylsulfonyl)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 355
• 1-[4-(4-{4-(1-hydroxy- 1-methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1 yl}phenyl)-2- thienyl]ethanone;
• 356
• 2-(1-{4-[5- (hydroxymethyl)-3- thienyl]phenyl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
• 357
• 4-(2-chlorophenyl)-5- {5-[3- (methylsulfonyl)phenyl]- 2-thienyl}-2- (trifluoromethyl)-1H- imidazole;
• 358
• 2-(2-chlorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-4- (trifluoromethyl)-1H- imidazole;
• 359
• 4-(2-chlorophenyl)-5-[3′- (methylsulfonyl)biphenyl- 4-yl]-2- (trifluoromethyl)-1H- imidazole;
• 360
• 4′-[2-(2-chlorophenyl)- 4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl- 3-sulfonamide;
• 361
• 4′-[4-(2-chlorophenyl)- 2-(trifluoromethyl)-1H- imidazol-5-yl]biphenyl- 3-sulfonamide;
• 362
• 3-{5-[4-(2- chlorophenyl)-2- (trifluoromethyl)-1H- imidazol-5-yl]-2- thienyl}benzenesulfonamide;
• 364
• 1-[3′- (methylsulfonyl)biphenyl- 4-yl]-4- (trifluoromethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazole;
• 365
• 4′-{4-(trifluoromethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3-sulfonamide;
• 367
• ethyl 1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazole-4- carboxylate;
• 369
• 5-[3- (methylsulfonyl)phenyl]-2-{4- (trifluoromethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}pyridine;
• 370
• 2-[2-(2-chlorophenyl)- 4-(trifluoromethyl)-1H- imidazol-l-yl]-5-[3- (methylsulfonyl)phen- yl]pyridine;
• 371
• 2-{1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 372
• 5-{3-[(1- methylethyl)sulfonyl]phenyl}- 2-{4-(trifluoromethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}pyridine;
• 373
• 1-{3′-[(1- methylethyl)sulfonyl]bi- phenyl-4-yl}-4- (trifluoromethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazole;
• 375
• N-(4′-{4- (trifluoromethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- yl)methanesulfonamide;
• 376
• ethyl 1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-phenyl-1H- imidazole-4-carboxylate;
• 378
• 2-{1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-phenyl-1H- imidazol-4-yl}propan-2-ol;
• 379
• 2-{2-(2-chlorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 380
• 2-{2-(2-fluorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 382
• 2-{2-(2,3- dichlorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 383
• 2-{2-(2-chloro-3- fluorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 384
• 4′-[2-(2-chlorophenyl)- 4-(1-hydroxy-1- methylethyl)-1H- imidazol-l-yl]biphenyl- 3-sulfonamide;
• 385
• 2-{2-(4-fluorophenyl)-1-[3′- (methylsulfony)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 386
• 2-{2-(2-chlorophenyl)- 1-[3-fluoro-3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 387
• 2-{2-(2-chlorophenyl)- 1-[2-fluoro-3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 388
• 2-{2-(2-chlorophenyl)- 1-[3′-(1- methylethyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 389
• 2-{2-(2-chlorophenyl)- 1-[4′-(1,1- dimethylethyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 390
• methyl 4′-[2-(2- chlorophenyl)-4-(1- hydroxy-1- methylethyl)-1H- imidazol-1-yl]biphenyl- 3-carboxylate;
• 391
• N-{4′-[2-(2- chlorophenyl)-4-(1- hydroxy-1- methylethyl)-1H- imidazol-1-yl]biphenyl- 3-yl}-1,3- benzodioxole-5- carboxamide;
• 392
• 2-{1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[3- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 393
• 2-{2-(3-chlorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 394
• 2-{2-(2-chloro-6- methylphenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 395
• 4′-[2-(2-chlorophenyl)- 4-(1-hydroxy-1- methylethyl)-1H- imidazol-1-yl]biphenyl- 3-carboxylic acid;
• 397
• 2-(2-chlorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-N-(2,2,2- trifluoroethyl)-1H- imidazole-4- carboxamide;
• 399
• 2-{1-[4′-(methyloxy)-3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 400
• 2-{1-[4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 401
• ethyl 4′-{4-(1-hydroxy- 1-methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1-yl}-5- (methylsulfonyl)biphenyl- 3-carboxylate;
• 402
• 2-{5-bromo-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 403
• 2-{5-chloro-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 404
• 2-{1-[4′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 405
• 2-[1-(3′-aminobiphenyl- 4-yl)-2-(2- chlorophenyl)-1H- imidazol-4-yl]propan-2-ol;
• 406
• 2-{5-fluoro-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 407
• 2-{1-[4′- (methylsulfonyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 409
• 2-{2-(2-chlorophenyl)- 1-[3′-(1-hydroxy-1- methylethyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 410
• 2-{2-(2,6- difluorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 413
• 2-(1-{3-[(1- methylethyl)sulfonyl]bi- phenyl-4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
• 414
• 2-(1-{3′-[(1- methylethyl)sulfonyl]bi- phenyl-3-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
• 415
• 2-{2-(2-chlorophenyl)-1-[3′- (ethylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 416
• 2-{2-(2-chloro-6- fluorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 417
• 2-{1-[3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl]-2-(2- chlorophenyl)-1H- imidazol-4-yl}propan-2-ol;
• 418
• 2-{2-(2-chlorophenyl)- 1-[3-methyl-3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 419
• 2-{2-[2,6- difluorophenyl)-1-[3′- (ethylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 420
• 2-(1-{5-[3- (methylsulfonyl)phen- yl]pyridin-2-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
• 421
• 2-(1-{6-[3- (methylsulfonyl)phen- yl]pyridin-3-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
• 422
• 2-{2-(2,6- dichlorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 427
• 2-{2-(2,3- dichlorophenyl)-1-[3′- (ethylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 428
• 2-{5-methyl-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
• 429
• 2-{2-(2-chlorophenyl)- 1-[3′-(ethylsulfonyl)-3- fluorobiphenyl-4-yl]- 1H-imidazol-4- yl}propan-2-ol;
• 430
• 2-{2-[2-fluoro-6- (trifluoromethyl)phenyl]- 1-[3′-(methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 431
• 2-{2-(2-methylphenyl)- 1-[3′-(methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 432
• 2-(1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-{2- [(trifluoromethyl)oxy]phen- yl}-1H-imidazol-4- yl)propan-2-ol;
• 436
• 2-(1-(2′,5′- dimethylbiphenyl-4-yl- 2-(2-trifluoromethyl)phen- yl)1H-imidazol-4- yl)propan-2-ol;
• 437
• 2-{2-(2-chlorophenyl)- 1-[3′-(ethylsulfonyl)-2- fluorobiphenyl-4-yl]- 1H-imidazol-4- yl}propan-2-ol;
• 438
• 2-{2-(3-chloro-2- methylphenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 439
• 2-{2-(2-chlorophenyl)- 1-[2-methyl-3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 440
• 2-{2-(3-chloro-2- methylphenyl)-1-[3′- (ethylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
• 443
• 2-(1-(2-chlorobenzyl)-2-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
• 444
• 2-(1-(2,3- dichlorobenzyl)-2-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
• 445
• 2-(5-chloro-2-(3- chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-1-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol
• 446
• 2-(5-chloro-1-(2,6- dichlorophenyl)-2-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
• 447
• 3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl)-3- (methylsulfonyl)biphenyl- 4-carboxylic acid
• 448
• 3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl)- N-methoxy-N-methyl-3- (methylsulfonyl)biphenyl- 4-carboxamide
• 449
• 2-(2-(2,3- dichlorobenzyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
• 450
• 2-(2-(2,3- dichlorobenzyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol
• 451
• 2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2-(2,3- dichlorophenyl)propan- 2-yl)-1H-imidazol-4- yl)propan-2-ol
• 452
• 2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2-(2,3- dichlorophenyl)propan- 2-yl)-1H-imidazol-4- yl)propan-2-ol
• 453
• 3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl)-3- (methylsulfonyl)biphenyl- 4-carboxamide
• 454
• 2-(1-(3-chloro-4′- methoxy-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-6- fluorophenyl)-1H- imidazol-4-yl)propan-2-ol
• 455
• 2-(2-(2,3- dichlorophenyl)-1-(4′- methoxy-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
• 456
• 2-(2-(2,3- dichlorobenzyl)-1-(4′- methoxy-3-methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
• 457
• 2-(1-(3-chloro-4′- methoxy-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,3- dichlorobenzyl)-1H- imidazol-4-yl)propan-2-ol
• 458
• 2-(2-(3-chloro-3′- (methylsulfonyl)biphenyl- 2-yl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
• 459
• 1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N- (2,2,2-trifluoroethyl)- 1H-imidazole-4- carboxamide
• 460
• 1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N-(2- fluoroethyl)-1H- imidazole-4- carboxamide
• 461
• 2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazole-4- carboxamido)acetic acid
• 462
• 1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N- (2,2,2-trifluoroethyl)- 1H-imidazole-4- carboxamide
• 463
• 1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N-(1- hydroxy-2- methylpropan-2-yl)- 1H-imidazole-4-carboxamide
• 464
• 1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N-(1- hydroxy-2- methylpropan-2-yl)- 1H-imidazole-4-carboxamide
• 465
• N-tert-butyl-1-(3- chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazole-4-carboxamide
• 466
• 2-chloro-4′-(2-(2,6- dichlorophenyl)-4-(2- hydroxypropan-2-yl)- 1H-imidazol-1-yl)-3′- methylbiphenyl-4- carboxylic acid
• 467
• 2-(1-(2′,3-dichloro-5′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol
• 468
• 2-(1-(2′-chloro-3- methyl-5′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,3- dichlorobenzyl)-1H- imidazol-4-yl)propan-2-ol
• 469
• 6-{3-chloro-4-[2-(2- chloro-6-fluorophenyl)- 4-(1-hydroxy-1- methylethyl)-1H- imidazol-1-yl]phenyl}- 2,3-dihydro-1- benzothiophene-3-ol 1,1-dioxide
• 470
• 1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N-(2- hydroxyethyl)-1H- imidazole-4- carboxamide
• 471
• 1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N-(2- hydroxyethyl)-1H- imidazole-4-carboxamide
• 472
• 1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N-(2- hydroxy-2- methylpropyl)-1H- imidazole-4- carboxamide
• 473
• 1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N-(2- hydroxy-2- methylpropyl)-1H- imidazole-4-carboxamide
• 474
• 2-(2-(5-chloro-2- fluorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
• 475
• 2-(2-(2,3- dichlorophenyl)-1-(4′- (hydroxymethyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
• 476
• 2-(2-(2,3- dichlorophenyl)-1-(3′- (hydroxymethyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
• 477
• 2-(2-(2,3- dichlorophenyl)-1-(4′- (2-hydroxypropan-2- yl)biphenyl-4-yl)-1H- imidazol-4-yl)propan-2-ol
• 478
• 2-(2-(2,3- dichlorophenyl)-1-(3′- (2-hydroxypropan-2- yl)biphenyl-4-yl)-1H- imidazol-4-yl)propan-2-ol
• 479
• 2-(2-(2,6- dichlorophenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)-2-methylpropan-1-ol
• 480
• 1-(3-chloro-3′-(2- hydroxypropan-2- yl)biphenyl-4-yl)-2- (2,6-dichlorophenyl)-N- (1-hydroxy-2- methylpropan-2-yl)- 1H-imidazole-4-carboxamide
• 481
• 2-(2,6-dichlorophenyl)- N-(1-hydroxy-2- methylpropan-2-yl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazole- 4-carboxamide
• 482
• 2-(2-(5-chloro-2- fluorobenzyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
• 483
• 2-(2-(3-chloro-2- fluorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
• 484
• 2-(1-(3′- (methylsulfonyl)biphenyl- 4-yl)-2-(3- (trifluoromethyl)benzyl)- 1H-imidazol-4- yl)propan-2-ol
• 485
• 2-(1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(3- (trifluoromethyl)benzyl)- 1H-imidazol-4- yl)propan-2-ol
• 486
• 2-(2,6-dichlorophenyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-N-(1-hydroxy-2- methylpropan-2-yl)- 1H-imidazole-4- carboxamide, and
• 487
• N-tert-butyl-2-(2,6- dichlorophenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazole- 4-carboxamide.