Compounds and compositions as LXR modulators

A compound of Formula I:

• in which
• n is selected from 0, 1, 2 and 3;
• Z is selected from C and S(O);
• each Y is CR4;
• or one Y is CR4 and the other is N, thereby forming a pyridine-3-yl;
• or one Y is CR4 and the other is N, thereby forming a pyridine-2-yl;
• wherein R4 is selected from hydrogen, cyano, hydroxyl, C1-6alkyl, C1-6alkoxy, halo-substituted-C1-6alkyl and halo-substituted-C1-6alkoxy;
• R1 is selected from halo, cyano, hydroxyl, C1-6alkyl, C1-6alkoxy, halo-substituted-C1-6alkyl, halo-substituted-C1-6alkoxy and —C(O)OR4;
• wherein is selected from hydrogen, cyano, hydroxyl, C1-6alkyl, C1-6alkoxy, halo-substituted-C1-6alkyl and halo-substituted-C1-6alkoxy;
• R2 is selected from C6-10aryl, and C3-12cycloalkyl;
• wherein any aryl, or cycloalkyl of R2 is optionally substituted with 1 to 5 radicals independently selected from halo, hydroxy, cyano, nitro, C1-6alkyl, C1-6alkoxy, halo-substituted-C1-6alkyl, halo-substituted-C1-6alkoxy, —C(O)NR5R5, —OR5, —OC(O)R5, —NR5R6, —C(O)R5 and —NR5C(O)R5;
• wherein R5 and R6 are independently selected from hydrogen, C1-6alkyl, C1-6alkoxy, halo-substituted-C1-6alkyl, halo-substituted-C1-6alkoxy, C6-10aryl-C0-4alkyl, and C3-12cycloalkyl-C0-4alkyl;
• wherein any aryl, or cycloalkyl of R5 is optionally substituted with 1 to 4 radicals independently selected from halo, hydroxy, cyano, nitro, C1-6alkyl, C1-6alkoxy, halo-substituted-C1-6alkyl and halo-substituted-C1-6alkoxy;
• R3 is C5-10heteroaryl;
• wherein any heteroaryl of R3 is substituted with 1 to 5 radicals independently selected from halo, C1-6alkoxy, halo-substituted-C1-6alkyl, halo-substituted-C1-6alkoxy, —OXR7, —OXC(O)NR7R8, —OXC(O)NR7XC(O)OR8, —OXC(O)NR7XOR8, —OXC(O)NR7XNR7R8, —OXC(O)NR7XS(O)0-2R8, —OXC(O)NR7XNR7C(O)R8, —OXC(O)NR7XC(O)XC(O)OR8, —OXC(O)NR7R9, —OXC(O)OR7, —OXOR7, —OXR9, —XR9, —OXC(O)R9, —OXS(O)0-2R9 and —OXC(O)NR7CR7[C(O)R8]2;
• wherein:
• X is a selected from a bond and C1-6alkylene wherein any methylene of X can optionally be replaced with a divalent radical selected from C(O), NR7, S(O)2 and O;
• R7 and R8 are independently selected from hydrogen, cyano, C1-6alkyl, halo-substituted-C1-6alkyl, C2-6alkenyl and C3-12cycloalkyl-C0-4-alkyl;
• and wherein:
• when R3 is C5-10heteroaryl,
• then R9 is selected from C6-10aryl-C0-4-alkyl, and C3-12cycloalkyl-C0-4alkyl;
• wherein any alkyl of R9 can have a hydrogen replaced with —C(O)OR10;
• and any aryl, or cycloalkyl of R9 is optionally substituted with 1 to 4 radicals independently selected from halo, C1-6alkyl, C3-12cycloalkyl, halo-substituted-C1-6alkyl, C1-6alkoxy, halo-substituted-C1-6alkoxy, —XC(O)OR10, —XC(O)R10, —XC(O)NR10R10, —XS(O)0-2NR10R10 and —XS(O)0-2R10;
• wherein R10 is independently selected from hydrogen and C1-6alkyl;
• and a pharmaceutically acceptable salt or isomer thereof.