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US 8,569,342 B2Granted
Diastereomers of 4-aryloxy-3-hydroxypiperidines
AssigneeBrentwood Equities, Ltd.
InventorBalvinder Singh Rattan
Life of this patent
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Abstract
The present invention relates to essentially pure diastereomers of 4-aryloxy-3-hydroxypiperidines, including purified diastereomers of ifoxetine, methods of purifying said diastereomers, pharmaceutical compositions comprising said diastereomers and methods of treatment utilizing said pharmaceutical compositions.
Claims6
A method for inhibiting binding to 5-HT1A, 5-HT2B and 5-HT2C receptors comprising a pharmaceutical composition comprising:
- a compound, wherein the compound is an essentially pure diastereomer of a 4-aryloxy-3-hydroxypiperidine (1) or an addition salt thereof,
- wherein the diastereomer is in the (3R,4S) configuration, Ar is selected from a group consisting of 2,3-dimethylphenyl and 3,4-dimethylphenyl, R is selected from a group consisting of hydrogen and methyl, and the diastereomer is greater than about 90% purified from other isomers of formula 1.
Dependencies are inferred from the claim text.