Substituted benzo[f]lmidazo[1,2-d]pyrido[2,3-b][1,4]diazepine compounds

A compound of formula (I):

• or a pharmaceutically acceptable salt or ester thereof, wherein:
• Rz is H or C1-C6 alkyl;
• R1 is H, halogen, cyano, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C2-C6 alkenyl, unsubstituted or substituted C2-C6 alkynyl, or Q1-T1, wherein said substituted C1-C6 alkyl, substituted C2-C6 alkenyl, or substituted C2-C6 alkynyl is substituted with one or more groups independently selected from hydroxy, halogen, cyano, amino, and phenyl;
• R2 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, or Q2-T2;
• Q1 and Q2 are each independently a bond or C1-C6 alkyl linker;
• T1 is unsubstituted or substituted C6-C10 aryl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C10 carbocycle, unsubstituted or substituted heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, ORt, SRt, C(O)NRt′Rt, C(O)Rt, C(O)ORt, NRt′C(O)NRt″Rt, NRt′C(O)ORt, NRt′C(O)Rt, S(O)2Rt, or NRt′S(O)2Rt, wherein said substituted C6-C10 aryl, substituted heteroaryl, substituted C3-C10 carbocycle, or substituted heterocycle is substituted with one or more Rp, wherein each Rp is independently selected from:
• a) hydroxy, halogen, cyano, nitro,
• b) C1-C6 alkyl,
• c) C1-C6 alkoxy,
• d) amino, C1-C6 alkylamino, di-C1-C6 alkylamino,
• e) C6-C10 aryl,
• f) heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S,
• g) C3-C10 carbocycle,
• h) heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S,
• i) OR5, NRs,R5, SR5, C(O)R5, C(O)OR5, C(O)NRsR5, NRs′C(O)R5, NRs′C(O)OR5, NRs′C(O)NRsR5, S(O)2R5, and NRs′S(O)2R5,
• wherein R5 is H, C1-C6 alkyl, C6-C10 aryl-C1-C6 alkyl, C6-C10 aryl, heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, C3-C10 carbocycle, or heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S;
• and
• Rs and Rs′ are each independently H or C1-C6 alkyl;
• T2 is unsubstituted or substituted C6-C10 aryl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N,O and S, unsubstituted or substituted C3-C10 carbocycle, or unsubstituted or substituted heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, wherein said substituted C6-C10 aryl, substituted heteroaryl, substituted C3-C10 carbocycle, or substituted heterocycle is substituted with one or more groups independently selected from:
• a) hydroxy, halogen, cyano, nitro,
• b) C1-C6 alkyl,
• c) C1-C6 alkoxy,
• d) amino, C1-C6 alkylamino, di-C1-C6 alkylamino,
• e) C6-C10 aryl,
• f) heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S,
• g) C3-C10 carbocycle, and
• h) heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S;
• Rt is H, C1-C6 alkyl, C6-C10 aryl, heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, C3-C10 carbocycle, or heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S;
• Rt′ and Rt″ are each independently H or C1-C6 alkyl;
• m is 0, 1, 2, or 3;
• n is 0, 1, 2, 3, or 4;
• each R3 is independently halogen, cyano, nitro, hydroxy, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, amino, C1-C6 alkylamino, or di-C1-C6 alkylamino;
• and
• each R4 is independently halogen, cyano, nitro, hydroxy, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, amino, C1-C6 alkylamino, or di-C1-C6 alkylamino.