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US 8,569,320 B2Granted
Topical composition for the treatment of actinic keratosis
AssigneeAlmirall Hermal GmbH
InventorsManfred Melzer, Carmen Matthies, Klaus Treudler, Christoph Willers, Henning Mallwitz
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Abstract
The invention relates to a topical gel composition for use in the treatment of actinic keratosis comprising (a) an active agent for treatment of actinic keratosis, (b) a keratolytically active agent, (c) a gel former, and (d) an organic solvent.
Claims29
A method of treating actinic keratosis in a patient, said method comprising the step of:
- applying a topical gel composition to the affected area of skin, wherein the topical gel composition comprises:
- (a) 0.25 to 4.5 wt.-% of an active agent for treatment of actinic keratosis selected from the group consisting of cyclooxygenase inhibitors, topical immune modulators, antimetabolites, and mixtures thereof,
- (b) a keratolytically active agent selected from the group consisting of retinoid receptor agonists, urea, organic acids, and mixtures thereof,
- (c) a gel former, wherein the viscosity of the gel is in the range of 300 to 1500 m Pas at 20° C., and
- (d) an organic solvent,
- wherein said topical gel composition comprises less than 5 wt.-% water.
3 more elements
Dependencies are inferred from the claim text.