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US 8,569,309 B2Granted
4′-demethylepipodophyllotoxin derivative, preparation method and use thereof
AssigneeHubei University of Technology
InventorYaJie Tang
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Abstract
A 4′-demethylepipodophyllotoxin derivative of formula(III) having anti-tumor activity is provided. After the activation of hydroxyl in position C4 of 4′-demethylepipodophyllotoxin, tetramethylpyrazine is introduced by transamination to obtain the 4′-demethylepipodophyllotoxin derivative which is preferably used to inhibit gastric cancer line BGC-823.
Claims4
A compound with the structure shown in Formula (III) or its salts:
Dependencies are inferred from the claim text.