Carboxamide compounds and their use

A compound represented by the following formula:

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is hydrogen;
• alkyl, alkoxyalkyl, alkoxyphenyl, alkylthioalkyl, alkylamino, —SO2(alkyl), C3-6 cycloalkyl, C3-6 heterocycloalkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl, each of which is optionally substituted with 1, 2, or 3 R5 substituents;
• or R1 is optionally substituted (C1-C6alkylene)-R1a, wherein R1a is C3-6 cycloalkyl, C3-6 heterocycloalkyl, aryl, or heteroaryl, each of which is optionally substituted with 1, 2, or 3 R5 substituents;
• Y is a direct bond or is CO, SO2, —N(H)CO, —N(H)SO2, C(═NH), C1-4 alkylene, C2-4 alkenylene, C2-4 alkynylene, C3-6 cycloalkylene, arylene, heterocycloalkylene, heteroarylene, —C(O)alkylene, —N(H)C(O)alkylene, or —O-alkylene;
• each of which may be optionally substituted with 1, 2, or 3 R5 substituents;
• R3 is
• wherein R11 is hydrogen or is C1-6 alkyl, (C1-C6alkylene)cycloalkyl, aralkyl, or heteroaralkyl, any of which may be optionally substituted with halo, hydroxy, alkyl, alkenyl, cycloalkyl, C1-3alkoxy, —CO2H, —CO2C1-3alkyl, cyano, aryl, heteroaryl, —CF3, —O—CF3, —O—CH2F, or —O—CHF2;
• R4 is hydrogen;
• halo;
• C1-8 alkyl, alkenyl, or alkynyl optionally interrupted by oxygen or sulfur;
• cycloalkyl;
• alkoxy;
• arylalkoxy;
• or heteroarylalkoxy;
• R5, when present, represents independently for each occurrence hydrogen, halo, hydroxy, alkyl, alkenyl, cycloalkyl, alkoxy, —CO2H, —CO2C1-3alkyl, cyano, aryl, heteroaryl, aralkyl, heteroaralkyl, oxo, —CF3, —O—CF3, —O—CHF2, —O—CH2F, —O-aryl, —N(H)alkyl, —N(H)SO2-alkyl, —N(H)C(O)alkyl, —SO2N(H)alkyl, —SO2N(alkyl)C(O)alkyl, or —C(O)N(H)SO2alkyl;
• n is 0 or 1;
• p is 1;
• wherein R12 is, independently for each occurrence, hydrogen, halo, alkyl, haloalkyl, haloalkoxy, alkoxy, or cyano;
• and
• R13a and R13b are each independently hydrogen, halo, alkyl, haloalkyl, alkoxy, or haloalkoxy.