Method for modulating claudin mediated functions
AssigneesSucampo AG, Osaka University
InventorsRyuji Ueno, Sachiko Tsukita
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Abstract
Disclosed is a method for modulating a claudin-mediated function in a mammalian subject which comprises administering to a subject in need thereof an effective amount of a specific fatty acid derivative. The application also discloses a method for treating a dermatological disease and a method for modulating an expression of a claudin in a mammalian subject using the same fatty acid derivative as above.
Claims9
A method for treating skin ulcer or bed sore in a mammalian subject, which comprises administering to the subject in need thereof an effective amount of a fatty acid derivative which is (−)-7-{(2R,4aR,5R,7aR)-2-[(3S)-1,1-difluoro-3-methyl]pentyl]-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl}heptanoic acid or its salt, or ester.
A method for modulating a claudin-mediated function in a mammalian subject, which comprises administering to the subject in need thereof an effective amount of a fatty acid derivative which is (−)-7-{(2R,4aR,5R,7aR)-2-[(3S)-1,1-difluoro-3-methylpentyl]-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl}heptanoic acid or its salt, ester.
A method for modulating an expression of a claudin in a mammalian subject, which comprises administering to the subject in need thereof an effective amount of a fatty acid derivative which is (−)-7-{(2R,4aR,5R,7aR)-2-[(3S)-1,1-difluoro-3-methylpentyl]-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl}heptanoic acid or its salt, ester.
Dependencies are inferred from the claim text.