Vascular protecting agent having salt-absorption inhibitory activity
AssigneeMaruha Nichiro Foods, Inc.
InventorsItsuki Murota, Yoshio Uehara
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Abstract
This invention provides a vascular protecting agent having salt-absorption inhibitory activity with the use of alginate oligosaccharide salt absorbed by the body via degradation to an oligosaccharide, so that a patient can easily and safely ingest such agent on a routine basis. A vascular protecting agent having salt-absorption inhibitory activity comprises, as an active ingredient, alginate oligosaccharide obtained by treating sodium alginate with a Pseudoalteromonas microorganism or a processed product thereof and/or a salt thereof.
Claims12
A method for suppressing thickening of the blood vessel by inhibiting salt-absorption, which comprises administering an alginate oligosaccharide and/or salt thereof to a patient in need thereof, wherein the alginate oligosaccharide and/or salt thereof of formula 1:
- wherein in formula 1,
- R is a hydrogen atom or a metal ion;
- R′ is a structure selected from the group consisting of G;
- G-G;
- M-G;
- G-G-G;
- G-G-M;
- G-M-G;
- G-M-M;
- M-G-G;
- M-M-G;
- and M-M-M, wherein the linkage among D-mannuronic acid (M) and L-guluronic acid (G) is α- or β-1,4-bound.
A method for suppressing cardiac hypertrophy by protecting a vascular, which comprises administering an alginate oligosaccharide and/or salt thereof to a patient in need thereof, wherein the alginate oligosaccharide and/or salt thereof of formula 1:
- wherein in formula 1,
- R is a hydrogen atom or a metal ion;
- R′ is a structure selected from the group consisting of G;
- G-G;
- M-G;
- G-G-G;
- G-G-M;
- G-M-G;
- G-M-M;
- M-G-G;
- M-M-G;
- and M-M-M, wherein the linkage among D-mannuronic acid (M) and L-guluronic acid (G) is α- or β-1,4-bound.
A method for suppressing renal hypertrophy and/or glomerular hardening by protecting a vascular, which comprises administering an alginate oligosaccharide and/or salt thereof to a patient in need thereof, wherein the alginate oligosaccharide and/or salt thereof of formula 1:
- wherein in formula 1,
- R is a hydrogen atom or a metal ion;
- R′ is a structure selected from the group consisting of G;
- G-G;
- M-G;
- G-G-G;
- G-G-M;
- G-M-G;
- G-M-M;
- M-G-G;
- M-M-G;
- and M-M-M, wherein the linkage among D-mannuronic acid (M) and L-guluronic acid (G) is α- or β-1,4-bound.
Dependencies are inferred from the claim text.