Low density lipoprotein receptor-mediated siRNA delivery
AssigneeAlcon Research, Ltd.
InventorJon E. Chatterton
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Abstract
The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in vivo. The conjugates comprise a ligand that can bind to a low density lipoprotein receptor (LDLR) or LDLR family member. Therapeutic uses for the conjugates are also provided.
Claims12
A method of delivering an interfering RNA molecule to an eye of a patient, comprising administering to an eye of the patient an interfering RNA delivery conjugate comprising an interfering RNA molecule, a ligand that comprises the LDLR biding domain of apolipoprotein E (apoE), and an HA2 peptide.
Dependencies are inferred from the claim text.