Glutathione based delivery system

A method of traversing a blood brain barrier, comprising:

• administering a delivery system to a subject in need thereof, said delivery system comprising:
• a carrier;
• and
• glutathione,
• wherein the carrier is a nanoparticle, a polymeric nanoparticle, a solid liquid nanoparticle, a polymeric micelle, a liposome, a microemulsion, or a liquid-based nanoparticle, and
• wherein said glutathione is covalently bound to polyethylene glycol, wherein the polyethylene glycol is covalently bound to vitamin E or a phospholipid, and wherein the vitamin E or phospholipid is intercalated into the carrier, such that the glutathione is on an outside surface of the carrier.

A method of traversing a blood brain barrier, comprising:

• administering a delivery system to a subject in need thereof, said delivery system comprising:
• a carrier comprising a glutathione derivative,
• wherein the carrier is selected from group consisting of:
• a nanoparticle, a polymeric nanoparticle, a solid liquid nanoparticle, a polymeric micelle, a liposome, a microemulsion, and a liquid-based nanoparticle,
• wherein said glutathione derivative is covalently bound to a polyethylene glycol derivative which is itself covalently bound to a vitamin E derivative or a phospholipid,
• wherein said polyethylene glycol derivative is selected from the group consisting of:
• polyethylene glycol, a polyethylene glycol comprising carboxylic acid, a polyethylene glycol comprising maleimide, a polyethylene glycol comprising an amide, and a polyethylene glycol comprising biotin,
• wherein said vitamin E derivative is selected from the group consisting of vitamin E, α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, α-tocopherol succinate, β-tocopherol succinate, γ-tocopherol succinate, δ-tocopherol succinate, α-tocotrienol succinate, β-tocotrienol succinate, γ-tocotrienol succinate, δ-tocotrienol succinate, α-tocopherol acetate, β-tocopherol acetate, γ-tocopherol acetate, δ-tocopherol acetate, α-tocotrienol acetate, β-tocotrienol acetate, γ-tocotrienol acetate, δ-tocotrienol acetate, α-tocopherol nicotinate, β-tocopherol nicotinate, γ-tocopherol nicotinate, δ-tocopherol nicotinate, α-tocotrienol nicotinate, β-tocotrienol nicotinate, γ-tocotrienol nicotinate, δ-tocotrienol nicotinate, α-tocopherol phosphate, β-tocopherol phosphate, γ-tocopherol phosphate, δ-tocopherol phosphate, α-tocotrienol phosphate, β-tocotrienol phosphate, γ-tocotrienol phosphate, and δ-tocotrienol phosphate, and
• wherein the phospholipid has the structure of formula (II):
• wherein A2 is phosphoethanoamine and R2 is selected from the group consisting of:
• myristoyl, palmitoyl, stearoyl, and oleoyl,
• wherein the glutathione is on an outside surface of the carrier.