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US 8,569,034 B2Granted
Thermolysin variants and detergent compositions therewith
AssigneeDanisco US Inc.
InventorsDavid A. Estell, Ronaldus W. J. Hommes, Amy D. Liu, Andrew Shaw
Life of this patent
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Abstract
The present invention provides methods and compositions comprising at least one thermolysin-like neutral protease enzyme with improved storage stability and/or catalytic activity. In some embodiments, the thermolysin finds use in cleaning and other applications comprising detergent. In some particularly preferred embodiments, the present invention provides methods and compositions comprising thermolysin formulated and/or engineered to resist detergent-induced inactivation.
Claims20
A composition comprising:
- (i) an isolated thermolysin variant, having at least 95% amino acid identity with SEQ ID NO:
- 3 and having a substitution at position Y151 (tyrosine), wherein the thermolysin variant has activity to cleave at the N-terminal of hydrophobic amino acids and
- (ii) the neutral metalloprotease inhibitor galardin.
Dependencies are inferred from the claim text.