Back to results
US 8,568,995 B2Granted
Methods for assessing modified LDL immune complexes in subjects having or at risk of coronary artery disease
AssigneesMUSC Foundation for Research Development, Department of Veterans Affairs
InventorsMaria F. Lopes-Virella, Gabriel T. Virella
Life of this patent
Estimating the term…
Abstract
The present invention relates to the analysis of modified LDL in the context of immune complexes. In particular, ox-LDL and AGE-LDL are shown to predict the development of coronary artery disease and other micro- and macrovascular disorders, particularly in the context of diabetes.
Claims20
A method of predicting risk of coronary artery disease (CAD) in a subject comprising:
- (a) providing a modified low density lipoprotein-immune complex (mod-LDL-IC)-containing sample from said subject;
- (b) measuring oxidized-LDL immune complexes (ox-LDL-IC) and/or advanced glycation endproduct-LDL immune complexes (AGE-LDL-IC) in said sample;
- (c) comparing the amount of ox-LDL-IC and/or AGE-LDL-IC in said sample to a normal standard;
- and
- (d) predicting that said subject is at risk of developing CAD where an elevated amount of ox-LDL-IC and/or AGE-LDL-IC as compared to said standard is observed, or predicting that said subject is at not risk of developing CAD based where an elevated amount of ox-LDL-IC and/or AGE-LDL-IC as compared to said standard is not observed.
2 more elements
Dependencies are inferred from the claim text.