Breast endothelial cell expression patterns
AssigneesGenzyme Corporation, The Johns Hopkins University
InventorsSaraswati Sukumar, Stephen L. Madden
Life of this patent
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Abstract
To gain a better understanding of breast tumor angiogenesis, breast endothelial cells (ECs) were isolated and evaluated for gene expression patterns. When transcripts from breast ECs derived from normal and malignant breast tissues were compared, genes that were specifically elevated in tumor-associated breast endothelium were revealed. These results confirm that neoplastic and normal endothelium in human breast are distinct at the molecular level, and have significant implications for the development of anti-angiogenic therapies in the future.
Claims13
A method to aid in diagnosing breast tumor, comprising the steps of:
- detecting an expression product of at least one gene in a first breast tissue sample suspected of being neoplastic wherein said one gene is snail homolog 1 (Drosophila);
- comparing expression of the at least one gene in the first breast tissue sample with expression of the at least one gene in a second breast tissue sample which is normal and
- identifying the first breast tissue sample as likely to be neoplastic when expression of the one gene in the first breast tissue sample is increased relative to the second tissue sample.
Dependencies are inferred from the claim text.