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US 8,568,792 B2Granted
Metal compounds, mixed or sulphated, as phosphate binders
AssigneeCytochroma Development Inc.
InventorsNorman B Roberts, Maurice Webb, Benjamin J Rankin
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AssigneeCytochroma Development Inc.
InventorsNorman B Roberts, Maurice Webb, Benjamin J Rankin
Estimating the term…
A mixed metal compound for pharmaceutical use is free from aluminium and has a phosphate binding capacity of at least 30%, by weight of the total weight of phosphate present, over a pH range of from 2-8. The compound is especially useful for treatment of hyperphosphataemia. The metals are preferably iron (III) and at least one of calcium, magnesium, lanthanum and cerium. A metal sulphate for pharmaceutical use is selected from at least one of calcium, lanthanum and cerium sulphate compounds and has a phosphate binding capacity of at least 30% by weight of the total phosphate present, over a pH range from 2-8.
A pharmaceutical composition comprising a pharmaceutically acceptable phosphate-binding, mixed metal compound, wherein said compound is free from aluminum and contains iron (III), at least one additional metal M selected from the group consisting of magnesium, calcium, lanthanum and cerium, and a metal sulphate, and wherein the composition is effective for binding phosphate in animal.
A method for binding phosphate in an animal in need thereof, which comprises administering to said animal, a therapeutically effective amount of a pharmaceutically acceptable phosphate-binding, inorganic mixed metal compound, wherein said compound is free of aluminum and contains iron (III) and at least one additional metal M selected from the group consisting of magnesium, calcium, lanthanum and cerium.
Dependencies are inferred from the claim text.