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US 8,568,747 B1Granted
Enalapril compositions
AssigneesSilvergate Pharmaceuticals, Inc., University of Kansas
InventorsLian G. Rajewski, Roger A. Rajewski, John L. Haslam, Kathleen Heppert, Michael C. Beckloff, Frank Seagrave, Robert Mauro, Peter Colabuono
Life of this patent
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Abstract
Provided herein are stable enalapril powder compositions for oral liquid formulation. Also provided herein are methods of using enalapril oral liquid formulations for the treatment of certain diseases including hypertension, heart failure and asymptomatic left ventricular dysfunction.
Claims6
A pharmaceutical powder that is reconstituted into an oral liquid formulation, the powder consisting of:
- (a) about 14% (w/w) enalapril or a pharmaceutically acceptable salt thereof,
- (b) about 85% (w/w) mannitol, and
- (c) about 1% (w/w) colloidal silicon dioxide,
- wherein, when the powder is reconstituted into an oral liquid, the liquid is homogenous and stable for at least 12 weeks at about 25±5° C. and 55±10% relative humidity.
1 more element
Dependencies are inferred from the claim text.