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US 8,543,184 B2Granted
Silicone based membranes for use in implantable glucose sensors
AssigneeDexCom, Inc.
InventorsRobert Boock, Monica Rixman
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Abstract
Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.
Claims16
A transcutaneous implantable continuous analyte sensor, comprising:
- a working electrode configured to be transcutaneously implanted;
- and
- a membrane disposed over at least a portion of the working electrode, the membrane comprising a blend, the blend comprising a silicone-containing polymer and a hydrophilic polymer;
- wherein the membrane is configured to reduce or block passage therethrough of acetaminophen, whereby when:
- (1) the sensor is placed in a 2L bath filled with phosphate buffered saline, continuously stirred, brought to a temperature of 37° C., allowed to equilibrate for 1 hour until the sensor reaches a flat line continuous baseline signal;
- and
- (2) acetaminophen is then added to the bath to a dilution of 3.8 mg/dL and the sensor is then allowed to equilibrate over 1 hour while measurements are continuously recorded from the sensor;
- the signal does not change by more than 1%.
5 more elements
A transcutaneous implantable continuous analyte sensor, comprising:
- a working electrode configured to be transcutaneously implanted;
- and
- a membrane disposed over the working electrode, the membrane comprising:
- a first domain comprising a blend of a silicone-containing polymer and a hydrophilic polymer, the first domain configured to reduce permeability of acetaminophen;
- a second domain comprising an enzyme configured to react with an analyte;
- and
- a third domain comprising ionic components configured to reduce permeability of the third domain to an interfering species;
- wherein the first domain is configured to reduce or block passage therethrough of acetaminophen, whereby when:
- (1) the sensor is placed in a 2L bath filled with phosphate buffered saline, continuously stirred, brought to a temperature of 37° C., allowed to equilibrate for 1 hour until the sensor reaches a flat line continuous baseline signal;
- and
- (2) acetaminophen is then added to the bath to a dilution of 3.8 mg/dL and the sensor is then allowed to equilibrate over 1 hour while measurements are continuously recorded from the sensor;
- the signal does not change by more than 1%.
9 more elements
Dependencies are inferred from the claim text.