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US 8,543,182 B2Granted
Implantable biosensor and methods of use thereof
AssigneeMetronom Health, Inc.
InventorsElliot Botvinick, Troy M. Bremer
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Abstract
Provided herein is a stabilized oxygen transport matrix that includes a reversible oxygen binding protein, such as hemoglobin, immobilized throughout the stabilized oxygen transport matrix. The stabilized oxygen transport matrix is used to transport oxygen and can be used as an oxygen transport region and a reaction region of an analyte sensor, such as an implantable glucose sensor. The reversible binding protein can also function as an oxygen probe within the analyte sensor.
Claims15
A device, comprising:
- a) a first oxygen permeable surface;
- b) a second oxygen permeable surface;
- and
- c) a stabilized oxygen transport matrix in between the first and second oxygen permeable surfaces, wherein the stabilized oxygen transport matrix comprises a reversible oxygen binding protein immobilized throughout the stabilized oxygen transport matrix, and wherein the stabilized oxygen transport matrix transports oxygen from the first oxygen permeable surface to the second oxygen permeable surface.
1 more element
Dependencies are inferred from the claim text.