Method for selectively crystallizing a Z isomer of iopromide
AssigneeDaewoong Pharmaceutical Co., Ltd.
InventorsSoo-Jin Choi, Byung-Goo Lee, Han-Kuk Lee, Young-Mook Lim, Wol-Young Kim, Joon-Hwan Lee
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Abstract
The present invention relates to a method for selectively crystallizing Z isomer of iopromide of formula (I) comprising a) dissolving a crude iopromide comprising a mixture of E and Z isomers or a concentrate thereof in an alcohol, and b) heating the resulting alcohol solution to obtain crystalline of Z isomer of iopromide; and a method for preparing a composition comprising the crystalline Z isomer of iopromide.
Claims12
A method for selectively crystallizing Z isomer of iopromide represented by the following formula (I):
- said method comprising:
- a) dissolving crude iopromide or a concentrate thereof containing E and Z form isomers in an alcohol;
- and
- b) heating the resulting alcohol solution of the crude iopromide or the concentrate at a temperature ranging from 80° C. to 180° C. for 6-48 hours to obtain a crystalline iopromide comprising Z form isomer in an amount of 85-100% based on the total amount of the crystalline Z isomer of iopromide.
A method for preparing a composition comprising Z isomer of iopromide of the following formula (I) comprising
- a) dissolving crude iopromide or a concentrate thereof containing E and Z form isomers in an alcohol;
- b) heating the resulting alcohol solution of the crude iopromide or the concentrate at a temperature ranging from 80° C. to 180° C. for 6-48 hours to obtain a crystalline iopromide comprising Z form isomer in an amount of 85-100% based on the total amount of the crystalline iopromide;
- and
- c) dissolving the crystalline iopromide in a solvent, together with a pharmaceutically acceptable excipient to give a composition comprising 32-40 wt % of Z1 isomer of iopromide and 38-46 wt % of Z2 isomer of iopromide,
Dependencies are inferred from the claim text.