Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation

A pharmaceutical composition comprising an effective amount of a compound having the following structure:

• or a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier.

A method of treating diabetes comprising administering to a patient in need thereof a pharmaceutically effective amount of a compound having the following structure:

• or a pharmaceutically acceptable salt thereof.

A method of treating Syndrome X comprising administering to a patient in need thereof a pharmaceutically effective amount of a compound having the following structure:

• or a pharmaceutically acceptable salt thereof.

A method of treating diabetes-related disorders comprising administering to a patient in need thereof a pharmaceutically effective amount of a compound having the following structure:

• or a pharmaceutically acceptable salt thereof.

A method of treating obesity comprising administering to a patient in need thereof a pharmaceutically effective amount of a compound having the following structure:

• or a pharmaceutically acceptable salt thereof.

A method of treating cardiovascular disease comprising administering to a patient in need thereof a pharmaceutically effective amount of a compound having the following structure:

• or a pharmaceutically acceptable salt thereof.

A method of treating cerebrovascular disease comprising administering to a patient in need thereof a pharmaceutically effective amount of a compound having the following structure:

• or a pharmaceutically acceptable salt thereof.

A method of treating peripheral vessel disease comprising administering to a patient in need thereof a pharmaceutically effective amount of a compound having the following structure:

• or a pharmaceutically acceptable salt thereof.

A method of treating lupus comprising administering to a patient in need thereof a pharmaceutically effective amount of a compound having the following structure:

• or a pharmaceutically acceptable salt thereof.

A method of treating polycystic ovary disease comprising administering to a patient in need thereof a pharmaceutically effective amount of a compound having the following structure:

• or a pharmaceutically acceptable salt thereof.

A method of treating carcinogenesis and hyperplasia comprising administering to a patient in need thereof a pharmaceutically effective amount of a compound having the following structure:

• or a pharmaceutically acceptable salt thereof.