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US 8,541,614 B2Granted
Process for the preparation of (−)-(4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester
AssigneeMetabolex, Inc.
InventorsDiego Broggini, Hartmut Burghard Zinser
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Abstract
The present invention is directed to a novel process for the preparation of (4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester, useful in the treatment of metabolic disorders and further to a process for the preparation of (4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid, a synthesis intermediate.
Claims27
A process for preparing the compound of formula (I):
- comprising:
- (a) reacting the compound of formula (IX-R):
- with an acid at a temperature of from about 70° C. to about 150° C. to yield the compound of formula (II):
- having an enantiomeric excess of about 99% or greater;
- (b) reacting the compound of formula (II) with a source of chlorine, neat or in an organic solvent, to yield the compound of formula (X):
- (c) reacting the compound of formula (X) with a compound of formula (XI):
- neat or in an organic solvent, to yield the compound of formula (I).
4 more elements
Dependencies are inferred from the claim text.