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US 8,541,608 B2Granted
Method for preparing a polymer conjugate
AssigneeNektar Therapeutics
InventorWen Zhang
Life of this patent
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Abstract
Provided herein is a straightforward and efficient method for covalently attaching a polyethylene glycol polymer to a taxane. The method involves, among other things, a step of reacting a taxame with a polyethylene glycol polymer comprising a functional group reactive with a functional group within said taxane in the presence of a coupling reagent and DPTS. The result of the reacting step is the formation of a polyethylene glycol-taxane conjugate.
Claims18
A method for covalently attaching a polyethylene glycol polymer to a taxane, said method comprising the step of:
- reacting a taxane with a polyethylene glycol comprising a functional group reactive with a functional group within said taxane in the presence of a coupling reagent and 4-(dimethylamino)-pyridinium-p-toluenesulfonate (DPTS), under conditions effective to promote reaction between said taxane and said polyethylene glycol to thereby faun a polyethylene glycol-taxane conjugate
- wherein said polyethylene glycol comprises the following structure:
- and wherein each n is from about 5 to about 400.
Dependencies are inferred from the claim text.