US 8,541,601 B2 · Piperazine dithioctate and pharmaceutical composition comprising the same

Abstract

The present invention relates to piperazine dithioctate, a novel addition salt of thioctic acid with a base and a pharmaceutical composition comprising the same. The piperazine dithioctate according to the present invention has good thermal and moisture stability and high water-solubility as well as dosage increase lower than other addition salts, thereby being effectively used for preparing a pharmaceutical composition for antioxidation or for preventing or treating diabetic polyneuropathy, etc.

Claims4

Dependent claims

A crystalline piperazine dithioctate of formula (I):

which shows an X-ray powder diffraction pattern characterized by peaks having I/Io values of at least 10% (I is the intensity of each peak;
Io is the intensity of the highest peak) at diffraction angles (2θ) of 13.9±0.2, 16.3±0.2, 17.1±0.2, 17.3±0.2, 18.2±0.2, 18.9±0.2, 20.5±0.2, 22.2±0.2, 22.8±0.2, 24.2±0.2, and 39.3±0.2.

Dependencies are inferred from the claim text.

Facts

Application

13/379,528Filed 18 Jun 2010

Priority

KR 10-2009-005633724 Jun 2009

Published

US 2012/0101107 A126 Apr 2012

Granted

24 Sep 2013

Term ends

Not estimatedThe source records don’t support an estimate.

Classification15 codes

C07D 339/02
Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms: five-membered rings
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…
A61P 3/04
Drugs for disorders of the metabolism: anorexiants; Antiobesity agents
A61P 3/06
Drugs for disorders of the metabolism: antihyperlipidemics

Piperazine dithioctate and pharmaceutical composition comprising the same

Life of this patent

Piperazine dithioctate and pharmaceutical composition comprising the same

Life of this patent

Abstract

Claims4