Inhibitors

A compound of formula (I):

• or a pharmaceutically acceptable salt, tautomer, or stereoisomers thereof wherein:
• X represents a bond or a —(CH2)m-group;
• m represents an integer selected from 1 to 3;
• R1 represents -aryl, —C1-6alkylaryl, -cycloalkyl, —C1-6alkylcycloalkyl, —C1-6alkyl-Het, -aryl fused to heterocyclyl, —C1-6alkylaryl fused to heterocyclyl, -aryl substituted by heteroaryl, —C1-6alkylaryl substituted by heteroaryl, -aryl substituted by phenyl, —C1-6alkylaryl substituted by phenyl, -aryl substituted by phenoxy or —C1-6alkylaryl substituted by phenoxy;
• and in which any of aforesaid aryl, heterocyclyl, heteroaryl, phenyl or phenoxy groups may optionally be substituted by one or more groups selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, —C1-6thioalkyl, —SOC1-4alkyl, —SO2C1-4alkyl, C1-6alkoxy-, —O—C3-8cycloalkyl, C3-8cycloalkyl, —SO2C3-8cycloalkyl, —SOC3-6cycloalkyl, C3-6alkenyloxy-, C3-6alkynyloxy-, —C(O)C1-6alkyl, —C(O)OC1-6alkyl, C1-6alkoxy-C1-6alkyl-, nitro, halogen, cyano, hydroxyl, —C(O)OH, —NH2, —NHC1-4alkyl, —N(C1-4alkyl)(C1-4alkyl), —C(O)N(C1-4alkyl)(C1-4alkyl), —C(O)NH2, —C(O)NH(C1-4alkyl) and —C(O)NH(C3-10cycloalkyl);
• R2 represents -aryl, —C1-6alkylaryl, -cycloalkyl, —C1-6alkylcycloalkyl, —C1-6alkyl- Het, -aryl fused to heterocyclyl, —C1-6alkylaryl fused to heterocyclyl, -aryl substituted by heteroaryl, —C1-6alkylaryl substituted by heteroaryl, -aryl substituted by phenyl, —C1-6alkylaryl substituted by phenyl, -aryl substituted by phenoxy or —C1-6alkylaryl substituted by phenoxy;
• and in which any of aforesaid aryl, heterocyclyl, heteroaryl, phenyl or phenoxy groups may optionally be substituted by one or more groups selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, —C1-6thioalkyl, —SOC1-4alkyl, —S02C1-4alkyl, C1-6alkoxy-, —O—C3-8cycloalkyl, C3-8cycloalkyl, —SO2C3-8cycloalkyl, —SOC3-6cycloalkyl, C3-6alkenyloxy-, C3-6alkynyloxy-, —C(O)C1-6alkyl, —C(O)OC1-6alkyl, C1-6alkoxy-C1-6alkyl-, nitro, halogen, cyano, hydroxyl, —C(O)OH, —NH2, —NHC1-4alkyl, —N(C1-4alkyl)(C1-4alkyl), —C(O)N(C1-4alkyl)(C1-4alkyl), —C(O)NH2, —C(O)NH(C1-4alkyl) and —C(O)NH(C3-10cycloalkyl);
• Het represents a bicyclic heteroaryl group;
• in which said bicyclic heteroaryl group may be optionally substituted by one or more groups selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, —C1-6thioalkyl, —SOC1-4alkyl, —SO2C1-4alkyl, C1-6alkoxy-, —O—C3-8cycloalkyl, C3-8cycloalkyl, —SO2C3-8cycloalkyl, —SOC3-6cycloalkyl, C3-6alkenyloxy-, C3-6alkynyloxy-, —C(O)OC1-6alkyl, —C(O)OC1-6alkyl, C1-6alkoxy-C1-6alkyl-, nitro, halogen, cyano, hydroxyl, —C(O)OH, —NH2, —NHC1-4alkyl, —N(C1-4alkyl)(C1-4alkyl), —C(O)N(C1-4alkyl)(C1-4alkyl), —C(O)NH2, —C(O)NH(C1-4alkyl) and —C(O)NH(C3-10cycloalkyl).