Large substituent, non-phenolic opioids and methods of use thereof

A compound of formula:

• wherein R is —CH3, —CH2CH2CH(OH)C6H11, —CH2CH(CH2Ph)CONHCH2CO2H, —(CH—2)3CH(CH3)2 or —(CH2)3-2-thienyl;
• wherein Q is
• wherein
• is an aryl or heteroaryl residue of one to three rings;
• A is (CH2)n, wherein one or more CH2 may be replaced by —O—, cycloalkyl or CR1aR1b;
• R1a and R1b are chosen independently from hydrogen, halogen, lower alkyl, lower alkoxy and lower alkylthio;
• R10 is one or two residues chosen independently from hydrogen, hydroxyl, halogen, (C1-C6)alkyl, (C1-C6)alkoxy, halo(C1-C6)alkyl and halo(C1-C6)alkoxy and (C1-C6)alkylthio;
• R11 is H or
• is an aryl or heteroaryl residue of one to three rings;
• A′ is (CH2)m wherein one or more CH2 may be replaced by —O—, cycloalkyl, —CR1aR1b, —C(═O)— or —NH—;
• R12 is chosen from hydrogen and lower alkyl;
• R15 is one or two residues chosen independently from hydrogen, hydroxyl, halogen, (C1-C6)alkyl, (C1-C6)alkoxy, halo(C1-C6)alkyl and halo(C1-C6)alkoxy and (C1-C6)alkylthio;
• m is zero or an integer from 1 to 6;
• and
• n is an integer from 1 to 6;
• with the proviso that A is other than CH2.