Substituted sulfonamide compounds

A substituted sulfonamide compound corresponding to formula I:

• wherein
• n represents 0, 1 or 2;
• o represents 1, 2 or 3;
• p represents 1 or 2;
• q represents 0 or 1;
• r represents 0 or 1;
• the sum of p+q+r equals 3;
• Q represents a single bond, —O— or —CH2—;
• R1 represents aryl or heteroaryl or denotes an aryl or heteroaryl bonded via a C1-3-alkylene group;
• R2 represents H, C1-6-alkyl, C3-8cycloalkyl, aryl or heteroaryl;
• or denotes a C3-8-cycloalkyl, aryl or heteroaryl bonded via a C1-6-alkylene group, C2-6-alkenylene group or C2-6-alkynylene group;
• and
• R3 represents H, C1-6-alkyl, aryl or heteroaryl;
• or denotes an aryl or heteroaryl bonded via a C1-6-alkylene group, C2-6-alkenylene group or C2-6-alkynylene group;
• or
• R2 and R3 together form a heterocyclic ring, which optionally may be fused with an aryl or heteroaryl ring,
• wherein said heterocyclic ring may be saturated or mono- or polyunsaturated, but not aromatic, is 4-, 5-, 6- or 7-membered, and may contain in addition to the N hetero atom to which R2 is bonded, at least one further hetero atom or group selected from the group consisting of N, NR12, O, S, S═O and S(═O)2;
• wherein R12 represents H, C1-6-alkyl, —C(═O)—R13, C3-8-cycloalkyl, aryl, heteroaryl or a C3-8-cycloalkyl, aryl or heteroaryl bonded via a C1-3-alkylene group, and R13 denotes C1-6-alkyl, C3-8-cycloalkyl, aryl, heteroaryl or a C3-8-cycloalkyl, aryl or heteroaryl bonded via a C1-3-alkylene group,
• R4 and R5 each independently represent H, C1-6-alkenyl, C2-6-alkynyl, C3-8-cycloalkyl, 3- to 8-membered heterocycloalkyl, aryl or heteroaryl or a C3-8-cycloalkyl, 3- to 8-membered heterocycloalkyl, aryl or heteroaryl bonded via a C1-3-alkylene group;
• or
• R4 and R5 together form an unsubstituted or mono- or polysubstituted heterocyclic ring, which optionally may be fused with a saturated or mono- or polyunsaturated or aromatic, unsubstituted or mono- or polysubstituted ring system,
• wherein said heterocyclic ring may be saturated or mono- or polyunsaturated but not aromatic, is 4-, 5-, 6- or 7-membered, and may contain in addition to the N hetero atom to which R4 and R5 are bound, at least one hetero atom or group selected from the group consisting of N, NR8, O, S, S═O and S(═O)2, wherein R8 represents a moiety selected from the group consisting of H, C1-6-alkyl, C3-8-cycloalkyl, aryl, heteroaryl, and aryl, or denotes heteroaryl or C3-8-cycloalkyl bonded via a C1-3-alkylene group, and
• wherein said ring system is 4-, 5-, 6- or 7-membered, and optionally may contain at least one hetero atom or group selected from the group consisting of N, NR17, O, S, S═O and S(═O)2, wherein R17 represents a moiety selected from the group consisting of H, C1-6-alkyl, C3-8-cycloalkyl, aryl, heteroaryl and aryl, or denotes heteroaryl or C3-8-cycloalkyl bonded via a C1-3-alkylene group;
• R6 represents H, C1-6-alkyl, or aryl, or denotes a C3-8cycloalkyl bonded via a C1-3-alkylene group, an aryl bonded via a C1-3-alkylene group or a heteroaryl bonded via a C1-3-alkylene group, and
• R7 represents C1-6-alkyl, C2-6-alkenyl or C2-6-alkynyl, C3-8cycloalkyl, aryl or heteroaryl;
• or denotes a C3-8-cycloalkyl, aryl or heteroaryl bonded via a C1-6-alkylene group;
• or
• R6 and R7 together with the —N—C(═O) group form a ring of the type
• wherein d represents 0 or 1 and R14 and R15 together represent an annellated unsubstituted or substituted aryl or heteroaryl group;
• wherein said C1-6-alkyl, C1-6-alkylene, C2-6-alkenylene, C2-6-alkynylene, C3-8-cycloalkyl, C3-8-heterocycloalkyl, aryl and heteroaryl groups each optionally may be unsubstituted or substituted one or more times by identical or different substituents;
• and said C1-6-alkyl, C1-6-alkylene, C2-6-alkenylene and C2-6-alkynylene groups each may be branched or unbranched;
• or a physiologically acceptable salt thereof.