US 8,541,572 B2 · Compounds for the treatment of inflammatory disorders

Compounds for the treatment of inflammatory disorders

AssigneeMerck Sharp & Dohme Corp.

InventorsJoseph A. Kozlowski, Wensheng Yu, Michael K. C. Wong, Seong Heon Kim, Ling Tong, Brian J. Lavey, Bandarpalle B. Shankar, De-Yi Yang, Robert Feltz, Aneta Maria Kosinski, Guowei Zhou, Razia K. Rizvi, Chaoyang Dai, Luke Fire, Vinay Girijavallabhan, Dansu Li, Janeta Popovici-Muller, Judson E. Richard, Kristin E. Rosner, M. Arshad Siddiqui, Liping Yang

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Abstract

This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF—or combinations thereof.

Claims4

Dependent claims

A compound selected from the group consisting of

and a pharmaceutically acceptable salt thereof.

Dependencies are inferred from the claim text.

Facts

Application

13/127,952Filed 9 Nov 2009 · us provisional application

Priority

10 Nov 2008

Published

US 2012/0010181 A112 Jan 2012

Granted

24 Sep 2013

Term ends

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Classification15 codes

C07D 403/14
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group…
A61P 1/00
Drugs for disorders of the alimentary tract or the digestive system
A61P 1/02
Drugs for disorders of the alimentary tract or the digestive system: stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61P 9/00
Drugs for disorders of the cardiovascular system