Compositions and methods using siRNA molecules for treatment of gliomas

A composition comprising at least three isolated siRNA molecules, wherein at least one isolated siRNA molecule (sense:

• 5′-CUGUAGACACACCCACCCACAUACA-3′ (SEQ ID NO:
• 10), antisense:
• 5′-UGUAUGUGGGUGGGUGUGUCUACAG-3′) (SEQ ID NO:
• 11) binds to an mRNA molecule that encodes a human VEGF protein and binds to an mRNA molecule that encodes a mouse VEGF protein, at least one isolated siRNA molecule (sense:
• 5′-CCAUCGAUGUCUACAUGAUCAUGGU-3′ (SEQ ID NO:
• 14), antisense:
• 5′-ACCAUGAUCAUGUAGACAUCGAUGG-3′) (SEQ ID NO:
• 15) binds to an mRNA molecule that encodes a human EGFR protein and binds to an mRNA molecule that encodes a mouse EGFR protein, and at least one isolated siRNA molecule (sense:
• 5′-GCUGAAGGUUGUGAAAUUCGGAGAA-3′ (SEQ ID NO:
• 18), antisense:
• 5′-UUCUCCGAAUUUCACAACCUUCAGC-3′) (SEQ ID NO:
• 19) binds to an mRNA molecule that encodes a human MGMT protein and binds to an mRNA molecule that encodes a mouse MGMT protein.