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US 8,541,564 B2Granted
Chemokine-immunoglobulin fusion polypeptides, compositions, method of making and use thereof
AssigneeMorehouse School of Medicine
InventorJames W. Lillard, Jr.
Life of this patent
Estimating the term…
Abstract
This application is directed to chemokine-immunoglobulin fusion polypeptides and chemokine-polymer conjugates. The fusion polypeptides and conjugates can be used for treating chemokine receptor-mediated disorders and modulating inflammation, inflammatory cell motility, cancer cell motility, or cancer cell survival.
Claims13
An isolated chemokine-immunoglobulin fusion polypeptide, comprising
- a chemokine moiety from human CLXCL11 and
- an immunoglobulin moiety from the constant region of human IgG1 (IgG1Fc), wherein the chemokine-immunoglobulin fusion polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NO:67, SEQ ID NO:68 and SEQ ID NO:69.
Dependencies are inferred from the claim text.