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US 8,541,560 B2Granted
Polypeptides comprising Fas activation and NKG2D-ligand domains
AssigneeThomas E. Wagner
InventorsThomas E. Wagner, Yanzhang Wei
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Abstract
The present invention is drawn to fusion proteins comprising (a) a ligand for an NK receptor and (b) a Fas activation domain, and to nucleic acids encoding such fusion proteins. The invention also includes methods of making and using such proteins and nucleic acids, including their use in preventing or treating cancer.
Claims9
A polynucleotide encoding the polypeptide comprising (i) a ligand for a stimulatory Natural Killer (NK) receptor and (ii) an intracytoplasmic death domain (DD), wherein the polynucleotide comprising nucleotides 7 to 1134 of SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.