Methods and compositions for delivering polynucleotides
AssigneeGencia Corporation
InventorShaharyar Khan
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Abstract
Methods and compositions for delivering polynucleotides are provided. One embodiment provides a non-viral vector comprising a recombinant polynucleotide-binding protein comprising a protein transduction domain operably linked to a targeting signal. Methods for modifying the genome of non-nuclear organelles are also provided.
Claims9
A transcription factor A-mitochondrial (TFAM) fusion protein comprising a protein transduction domain, a mitochondrial localization signal, and a mature transcription factor A-mitochondrial (TFAM),
- wherein the protein transduction domain comprises a plurality of amino acid residues having a net positive charge under physiological conditions.
A transcription factor A-mitochondrial (TFAM) fusion protein comprising a protein transduction domain, a mitochondrial localization signal, and a transcription factor A-mitochondrial (TFAM) polypeptide comprising amino acids 60-130 and 165-231 of SEQ ID NO:210.
Dependencies are inferred from the claim text.