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US 8,541,498 B2Granted
Lubricious coatings for medical devices
AssigneeBioInteractions Ltd.
InventorsShivpal S. Sandhu, Alan Rhodes, Simon Jon Onis
Life of this patent
Estimating the term…
Abstract
Substrates may be coated with copolymers of N-vinyl pyrrolidinone and aryl ketones. Processes are described for making the copolymers at high molecular weight with the ketones randomly dispersed on the copolymer.
Claims37
A coating on a medical device comprising
- a hydrophilic layer comprising copolymers covalently crosslinked by photoinitiation of diaryl ketones pendant on the copolymers,
- with the copolymers, before photoinitiation, being polymerized from a plurality of monomers comprising N-vinyl pyrrolidinone and diaryl ketone vinyl monomer, having a weight average molecular weight of more than about 100,000, at least about 60% by weight N-vinyl pyrrolidinone, no more than about 5% by weight of diaryl ketone monomer that provides the pendant diaryl ketones, and a random distribution of the diaryl ketones,
- wherein the coating has a friction coefficient of no more than about 0.2.
A coating on a medical device comprising
- a hydrophilic layer comprising copolymers covalently crosslinked by photoinitiation of diaryl ketones pendant on the copolymers,
- with the copolymers, before photoinitiation, being polymerized from a plurality of monomers comprising N-vinyl pyrrolidinone and diaryl ketone vinyl monomer, having a weight average molecular weight of more than about 100,000, at least about 60% by weight N-vinyl pyrrolidinone, no more than about 5% by weight of diaryl ketone monomer that provides the pendant diaryl ketones, and a random distribution of the diaryl ketones,
- wherein the copolymers, before photoinitiation, consist essentially of the polymerization product of the N-vinyl pyrrolidinone and the diaryl ketone monomer.
A coating on a medical device comprising
- a hydrophilic layer comprising copolymers covalently crosslinked by photoinitiation of diaryl ketones pendant on the copolymers,
- with the copolymers, before photoinitiation, being polymerized from a plurality of monomers comprising N-vinyl pyrrolidinone and diaryl ketone vinyl monomer, having a weight average molecular weight of more than about 100,000, at least about 60% by weight N-vinyl pyrrolidinone, no more than about 5% by weight of diaryl ketone monomer that provides the pendant diaryl ketones, and a random distribution of the diaryl ketones,
- wherein the plurality of monomers comprises a monomer that comprises a pendant group chosen from the group consisting of polyethylene glycol, a silyl pendant group, a zwitterionic group, a hydroxyl group, and a pendant group terminating in a sulfonate group.
A coating on a medical device comprising
- a hydrophilic layer comprising copolymers covalently crosslinked by photoinitiation of diaryl ketones pendant on the copolymers,
- with the copolymers, before photoinitiation, being polymerized from a plurality of monomers comprising N-vinyl pyrrolidinone and diaryl ketone vinyl monomer, having a weight average molecular weight of more than about 100,000, at least about 60% by weight N-vinyl pyrrolidinone, no more than about 5% by weight of diaryl ketone monomer that provides the pendant diaryl ketones, and a random distribution of the diaryl ketones,
- wherein the medical device is selected from the group consisting of a stent, a guidewire, a pacemaker lead, a catheter, a medical balloon, a nasogastric feeding tube, an endotracheal tube a PICC line, and a surface exposed to blood.
Dependencies are inferred from the claim text.