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US 8,541,484 B2Granted
PVA-PAA hydrogels
AssigneeThe General Hospital Corporation
InventorsJeeyoung Choi, Orhun K. Muratoglu
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Abstract
The invention provides fabricated PVA-hydrogels, PVA-hydrogel-containing compositions, and methods of making the same. The invention also provides methods of implanting or administering the PVA-hydrogels, or the PVA-hydrogel-containing compositions to treat a subject in need. Methods of cross-linking pre-solidified or pre-gelled hydrogel particles and making cross-linked PVA-hydrogels, and cross-linked PVA-hydrogel-containing compositions also are disclosed herein.
Claims23
A method of making a PVA-hydrogel comprising:
- a) contacting an aqueous solution of poly(vinyl alcohol) (PVA) with an aqueous solution of poly(acrylic acid) (PAA) at a temperature above the room temperature, thereby forming a homogenous PVA-PAA solution wherein the PVA-PAA solution includes no polyethylene glycol (PEG);
- b) pouring the PVA-PAA solution onto a mold followed by cooling down to room temperature, thereby allowing formation of the PVA-hydrogel;
- c) cooling the PVA-hydrogel by freezing at a temperature below 0° C.;
- d) thawing the PVA-hydrogel to a temperature above 0° C.;
- and
- e) immersing PVA-hydrogel in a PEG solution, thereby allowing diffusion of the PEG into the PVA-hydrogel.
3 more elements
Dependencies are inferred from the claim text.