Compounds for treatment of malignant tumors
AssigneesThe Trustees of the University of Pennsylvania, Wake Forest University Health Sciences, University of the Sciences in Philadelphia
InventorsConstantinos Koumenis, Brian E. Lally, Steven Kridel, Gary D. Kao, Adeboye Adejare
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Abstract
The present invention comprises compounds, compositions and methods of use for sensitizing cancer cells, tumors, neoplasms, and malignancies to the effects of ionizing radiation used in the treatment of cancer. The invention further comprises a method of identifying novel radiosensitizing compounds.
Claims12
A method of treating a mammal diagnosed with cancer, said method comprising administering to said mammal a therapeutically effective amount of a pharmacological composition comprising a compound of formula (I):
- wherein:
- Y is NO2, NR13, CN, CHO, C(O)R1 or CF3;
- X is H, F, Cl, Br or I;
- R is CN, CHO, C(O)R1, C(O)NH2, C(O)NHR1, C(O)NR1R2, S(O)mR1, S(O)2NH2, S(O)2NHR1, S(O)2NR1R2, P(O)(OH)R1, C(O)OH, or C(O)OR1;
- R1 and R2 each independently is CH3, CH2CH3, CH2CH2CH3, CH2CH2CH2CH3, CH(CH3)2, or C(CH3)3;
- and
- m is an integer of 0, 1 or 2;
- or a pharmaceutically acceptable salt,
- wherein said composition contacts a cancer cell or tumor in said mammal, thereby making said cancer cell or tumor more susceptible to the effects of ionizing radiation,
- wherein said cancer is at least one selected from the group consisting of glioma, colorectal cancer and non-small cell lung cancer.
A method of treating a mammal diagnosed with cancer, said method comprising administering to said mammal a therapeutically effective amount of a composition comprising Formula I,
- wherein Y═NO2, R═C(O)R1, R1═CH2CH3, and X═I, or a pharmaceutically acceptable salt thereof,
- wherein said composition contacts a cancer cell or tumor in said mammal, thereby making said cancer cell or tumor more susceptible to the effects of ionizing radiation,
- wherein said cancer is at least one selected from the group consisting of glioma, colorectal cancer and non-small cell lung cancer.
A method of treating a mammal diagnosed with cancer, said method comprising administering to said mammal a therapeutically effective amount of a composition comprising Formula I,
- wherein Y═NO2, R═S(O)2R1, R1═CH2CH3, and X═F or I, or a pharmaceutically acceptable salt thereof,
- wherein said composition contacts a cancer cell or tumor in said mammal, thereby making said cancer cell or tumor more susceptible to the effects of ionizing radiation
- wherein said cancer is at least one selected from the group consisting of glioma, colorectal cancer and non-small cell lung cancer.
A method of treating a mammal diagnosed with cancer, said method comprising administering to said mammal a therapeutically effective amount of a composition comprising Formula I,
- Y═NO2, R═P(O)(OH)R1, R1═CH2CH3, and X═F, Cl, Br, H, or I, or a pharmaceutically acceptable salt thereof,
- wherein said composition contacts a cancer cell or tumor in said mammal, thereby making said cancer cell or tumor more susceptible to the effects of ionizing radiation,
- wherein said cancer is at least one selected from the group consisting of glioma, colorectal cancer and non-small cell lung cancer.
Dependencies are inferred from the claim text.