Treatment of cell-mediated immune diseases
AssigneeGlaxo Group Limited
InventorsWerner Bollag, Fritz Ott
Life of this patent
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Abstract
9-cis retinoic acid and pharmaceutically acceptable salts and pharmaceutically acceptable hydrolyzable esters thereof, 9-cis retinal and pharmaceutically acceptable acetals thereof, and 9-cis retinol and pharmaceutically acceptable hydrolyzable esters thereof as well as metabolites of 9-cis retinoic acid have been found to be efficacious in treating T-helper cell type 1 mediated immune diseases in well tolerated doses. Preferably, the active ingredient is formulated as a medicament for oral or topical administration.
Claims13
A method of treating eczema in a human patient in need thereof, comprising orally administering to said patient a composition comprising a pharmaceutically active compound which is 9-cis retinoic acid or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent compatible with said active compound, and wherein the 9-cis retinoic acid is administered daily to said patient from about 0.05 to 1.5 mg per kg of body weight of the patient.
Dependencies are inferred from the claim text.