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US 8,541,459 B2Granted
Pharmaceutical composition
AssigneePola Pharma Inc.
InventorsYasushi Murakami, Naoko Kobayashi, Azuma Nishio, Nobuo Kubota
Life of this patent
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Abstract
To provide a pharmaceutical composition which can enhance the storage stability of 1-(1-hydroxymethyl-2,3-dihydroxypropyloxymethyl)-2-nitroimidazole without impairing the effect of the compound. The pharmaceutical composition includes 1-(1-hydroxymethyl-2,3-dihydroxypropyloxymethyl)-2-nitroimidazole, which is represented by formula (1): and a compound having chelating ability.
Claims24
A pharmaceutical composition, consisting essentially of:
- (1) 2 to 10 mass % of a 1-(1-hydroxymethyl-2,3-dihydroxypropyloxymethyl)-2-nitroimidazole, which is represented by formula (1):
- (2) 0.005 to 2 mass % of a compound having chelating ability;
- and
- (3) the balance water;
- wherein the compound having chelating ability is at least one species selected from the group consisting of a saccharic acid, a salt of a saccharic acid, an aminopolycarboxylic acid, a salt of an aminopolycarboxylic acid, an oxycarboxylic acid, a salt of an oxycarboxylic acid, an amine compound, and a polyoxyethylene castor oil.
2 more elements
Dependencies are inferred from the claim text.