Pyrazolopyridines

A compound represented by structural formula I or IA:

• or a pharmaceutically acceptable salt thereof wherein:
• each ring A is independently a five membered heteroaromatic ring,
• ring B is five- or six-membered saturated carbocyclic or heterocyclic ring;
• R2 is —H, —(CR++2)nCN, —(CR++2)nC(O)N(R*)2, —(CR++2)nOR*, —(CR++2)nN(R*)2, —(CR++2)nN(R*)C(O)R*, or C1-10 aliphatic optionally substituted with one or more halogen, or phenyl;
• each R3 and R4 independently are —H, halogen, C1-10 aliphatic, heterocyclyl, heterocyclylalkyl, aryl, or aralkyl, wherein R3 and R4 are optionally and independently substituted with one or more selected from the group consisting of C1-10 alkyl, halogen, —CN, —NO2, —N(R*)2, —S(O)pR*, —S(O)pNR*, —C(O)N(R*)2, —NR*C(O), —OC(O)N(R*)2, —N(R*)C(O)OR*, —N(R*)C(O)N(R*)2 and —OR*;
• or
• R3 and R4 taken together with the carbon to which they are attached form C═O, or a 3-8 membered saturated, partially saturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from the groups consisting of O, N, and S, wherein the ring is optionally and independently substituted with one or more selected from the group consisting of ═O, ═S, ═N—R*, C1-10 aliphatic, C1-10 haloaliphatic, halogen, —CN, —NO2, —N(R*)2, —S(O)pR*, —S(O)pNR*, —C(O)N(R*)2, —NR*C(O), —OC(O)N(R*)2, —N(R*)C(O)OR*, —N(R*)C(O)N(R*)2 and —OR*;
• each R5 and R6 are independently —H, halogen, C1-10 haloaliphatic, or C1-10 aliphatic;
• each R7 is independently C1-10 haloaliphatic, C1-10 aliphatic, halogen, —NO2, —(CR++2)nCN, —(CR++2)nN(R**)2, —(CR++2)nOR**, or —(CR++2)nC(O)N(R**)2, or two R7 groups together with the carbon to which they are attached form C═O;
• each R++ is independently —H or halogen;
• each R* is independently —H or C1-10 alkyl or aralkyl optionally and independently substituted with up to five halogen groups;
• each R** is independently —H or C1-10 alkyl optionally and independently substituted with up to five halogen groups;
• each n is independently 0, or 1-10;
• and
• each p is independently 0, 1, or 2.