Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines

A compound of the Formula (I):

• wherein:
• m is an integer from 1 to 5;
• R′ is selected from the group consisting of:
• hydroxy,
• thiol,
• —S(O)0-2-alkyl,
• —S(O)2—NH—R9,
• alkoxy,
• —O—C1-3 alkylene-S(O)2-alkyl,
• —N(R9)2, and
• —NH-Q-R4;
• Z is selected from the group consisting of:
• a bond,
• C1-5 alkylene,
• A′ is selected from the group consisting of:
• —O—,
• —C(O)—,
• —N(R8)—,
• —N(Q-R4)—,
• —N(C1-5 alkylene-NH-Q-R4)—,
• —N(C1-5 alkylene-W—NH—R8)—, and
• —S(O)0-2—;
• R2 is selected from the group consisting of:
• hydrogen, alkyl, alkoxyalkylenyl, haloalkyl, and hydroxyalkyl;
• when taken together, RA and RB form a fused 6-membered heteroaryl ring containing one N wherein the heteroaryl ring is unsubstituted or substituted by one R group;
• or when taken together, RA and RB form a fused 6-membered saturated ring, containing one N, and unsubstituted or substituted by one R groups;
• R is selected from the group consisting of:
• halogen,
• hydroxy,
• alkyl,
• alkenyl,
• haloalkyl,
• alkoxy,
• alkylthio, and
• —N(R9)2;
• R4 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, arylalkylenyl, aryloxyalkylenyl, alkylarylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, alkylheteroarylenyl, and heterocyclyl, wherein the alkyl, alkenyl, alkynyl, aryl, arylalkylenyl, aryloxyalkylenyl, alkylarylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, alkylheteroarylenyl, and heterocyclyl groups can be unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkoxy, hydroxyalkyl, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, mercapto, cyano, aryl, aryloxy, arylalkyleneoxy, heteroaryl, heteroaryloxy, heteroarylalkyleneoxy, heterocyclyl, amino, acetylamino, alkylamino, dialkylamino, (dialkylamino)alkyleneoxy, and in the case of alkyl, alkenyl, alkynyl, and heterocyclyl, oxo;
• R6 is selected from the group consisting of ═O and ═S;
• R8 is selected from the group consisting of hydrogen, alkyl, alkoxyalkylenyl, and arylalkylenyl;
• R9 is selected from the group consisting of hydrogen and alkyl;
• R11 is selected from the group consisting of hydrogen, alkyl, halogen, and trifluoromethyl;
• R12 is selected from the group consisting of hydrogen, alkyl, phenyl, 2-pyridyl, 3-pyridyl, and 4-pyridyl;
• Q is selected from the group consisting of a bond, —C(R6)—, —C(R6)—C(R6), —S(O)2—, —C(R6)—N(R8)—W—, —S(O)2—N(R8)—, —C(R6)—O—, and —C(R6)—N(OR9)—;
• and
• W is selected from the group consisting of a bond, —C(O)—, and —S(O)2—;
• with the proviso that when Z is a bond or C1-5 alkylene then R′ is other than —O—C1-3 alkylene-S(O)2-alkyl;
• or a pharmaceutically acceptable salt thereof.