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OwnerUday Saxena, Venkateswarulu Akellainventors
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The present invention discloses (1) phenolic ester hybrids of niacin with m-methoxy-p-hydroxy phenyl compounds like eugenol, vanillin, apocynin, ferulic acid, isoferulic acid and eugenol epoxide and (2) cocrystals of hybrids as above, particularly cocrystal of niacin-eugenol hybrid with cocrystal former like eugenol and oxalic acid (3) novel pharmaceutical compositions comprising a combination of niacin and one or more small molecule/potentiating agent like eugenol, curcumin, cinnamic acid, meclofenamic acid, and their use in the treatment of a disorder or a disease caused by excess production of amyloid beta peptide-42 (Aβ42), its deposition, accumulation, and plaque formation including Alzheimer's Disease, dementia and mild cognitive impairment as well as other neurodegenerative diseases such as Parkinson's Disease and ischemic stroke.
A pharmaceutical composition comprising a niacin hybrid resulting from esterification of niacin with apocynin and wherein the said composition is effective in treatment of a disorder or a disease characterized by excess production of amyloid beta peptide-42 (Abeta42), its deposition, accumulation, and plaque formation.
Dependencies are inferred from the claim text.