Fused thiazolo and oxazolo pyrimidinones

A Compound of formula (I)

• their pharmaceutically acceptable salts and their isomers, stereoisomers, conformers, tautomers, polymorphs, hydrates, and solvates;
• Wherein,
• When Y is NR4, O, S or SO2, m is 1 to 2 and when Y is C(R5)(R6), m is 1 to 4;
• n is 1 to 6;
• P is —OH, —OR7, —NH2, —NHR7, —NR7R7′, —NHSO2R7, —NHCOR7, —NHOH or —NHOR7;
• X is —OH, OR7, —SR7, —SOR7, —SO2R7, —NHR7 or —NR7R7′;
• Z is S or O;
• R is hydrogen, linear or branched (C1-C8)alkyl, —(C1-C8)alkylaryl or —(C1-C8)alkylheteroaryl;
• R1 and R2 are independently selected from hydrogen, linear or branched —(C1-C8)alkyl, —(C3-C7) cycloalkyl, aryl, heteroaryl, —CH2-aryl and —CH2-heteroaryl, or
• R1 and R2 may join together to form a 3-6 membered monocyclic or 9-12 membered bicyclic ring;
• R together with either R1 or R2 of adjacent carbon atom may form a 3-6 membered monocyclic or 8-11 membered bicyclic heteroaryl or heterocyclyl ring;
• R3 and R3′ at each occurance is independently selected from hydrogen, linear or branched (C1-C8)alkyl, (C1-C5) alkoxy and halo;
• R3 and R3′ may also present in gem di-halo, gem di-alkyl or spirocycoalkyl arrangement;
• R4 is selected from the group consisting of hydrogen, linear or branched (C1-C8) alkyl, (C3-C7) cycloalkyl, aryl, heteroaryl, —(C1-C8) alkyl-aryl, —(C1-C8)alkyl-heteroaryl, —(C1-C2)alkyl-heterocyclyl, —C(O)R8, —C(O)OR8, —C(O)NR8R9, —C(S)NR8R9 and —SO2R8, wherein aryl and heteroaryl radicals are optionally substituted with one or more substituent selected from the group consisting of —(C1-C8) alkyl, —(C3-C7) cycloalkyl, heterocyclyl, aryl, heteroaryl, —OH, -alkoxy, halo, CN, —CF3, —OCF3, —O-aryl, —SO2—(C1-C8)-alkyl, —SO2-aryl, —NH2, —NHR10, —NR10R10′, —NH—CO—(C1-C8) alkyl, —NH—SO2—(C1-C8)alkyl, —NH—SO2-aryl, —COOH, —C(O)NH-alkyl, —CONH-aryl, —CONH-heteroaryl, —C(O)O—(C1-C8)alkyl, —C(O)O -aryl, —SO2NH—(C1-C8)alkyl, —SO2NH-aryl and —SO2NH-heteroaryl;
• R5 and R6 are independently selected from the group consisting of hydrogen, linear or branched (C1-C8)alkyl, (C3-C7) cycloalkyl, aryl, heteroaryl, fluoro, —COOH, —CONH—(C1-C8)alkyl, —NHCO—(C1-C8)alkyl, —NHCO-aryl, —NHCO-heteroaryl, —NH—SO2(C1-C8)alkyl, —NH—SO2-aryl and —NH—SO2-heteroaryl;
• R5 and R6 may join together to form a 3-6 membered carbocyclic, heteroaryl or heterocyclyl ring;
• R7, R7′, R10 and R10′ are independently selected from linear or branched (C1-C8)alkyl, (C3-C7) cycloalkyl and —(C1-C8)alkylaryl;
• R7 and R7′ or R10 and R10′ together with nitrogen atom to which they are attached, may form 5-6 membered monocyclic or 8-14 membered bicyclic saturated and partially saturated ring;
• the ring may contain 1 to 3 heteroatom selected from N, S & O;
• wherein saturated and partially saturated ring may be optionally substituted with one or more substituent independently selected from the group consisting of —(C1-C8)alkyl, —(C3-C7) cycloalkyl, heterocyclyl, aryl, heteroaryl, —OH, -alkoxy, halo, —CN, —CF3, —OCF3, —O-aryl, —SO2—(C1-C8)-alkyl, —SO2-aryl, —NH2, —NHR10, —NR10R10′, —NH—CO—(C1-C8)alkyl, —NH—SO2—(C1-C8)alkyl, —NH—SO2-aryl, —COOH, —C(O)NH-alkyl, —CONH-aryl, —CONH-heteroaryl, —C(O)O —(C1-C8)alkyl, —C(O)O-aryl, —SO2NH—(C1-C8)alkyl, —SO2NH-aryl and —SO2NH-heteroaryl;
• R8 is selected from the group consisting of linear or branched (C1-C8) alkyl, (C3-C7) cycloalkyl, —(C1-C8)alkyl-(C3-C7)cycloalkyl, heterocyclyl, aryl, —(C1-C8)alkyl-aryl, —(C1-C2)alkyl-heterocyclyl, heteroaryl and —(C1-C8)alkyl-heteroaryl, wherein aryl and heteroaryl radicals are optionally substituted with one or more substituent selected from linear or branched (C1-C8)alkyl, (C3-C7)cycloalkyl, —(C1-C8)alkyl-(C3-C7)cycloalkyl, aryl, heteroaryl, heterocyclyl, —OH, alkoxy, halo, —CN, —CF3, —OCF3, —O-aryl, —SO2—(C1-C8)alkyl, —SO2-aryl, —NH2, —NHR10, —NR10R10′, —NH—CO—(C1-C8)alkyl, —NH—SO2—(C1-C8)alkyl, —C(O)OH, —C(O)NH—(C1-C8)alkyl, —CONH-aryl, —CONH-heteroaryl, —NHCONH—(C1-C8)alkyl, —NHCONH-aryl, —SO2NH—(C1-C8)alkyl, —SO2NH-aryl and —SO2NH-heteroaryl;
• R9 is hydrogen, linear or branched (C1-C8)alkyl or —(C1-C8)alkylaryl;
• R8 and R9 together with nitrogen atom to which they are attached, may form 5-6 membered saturated ring.