Heterocyclic derivatives, pharmaceutical compositions and methods of use thereof

A compound represented by the structure of Formula II:

• wherein
• R1 is oxo, R2 is a group of the formula A and is a single bond;
• or R1 is a group of the formula A, R2 is absent and is a double bond;
• A is represented by the structure:
• R3 and R4 are each independently selected from the group consisting of a linear or branched C1-C6 alkyl, a linear or branched C2-C6 alkenyl, a C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl, halo, hydroxy, alkoxy, aryloxy, amino, cyano and nitro;
• R5 and R6 are each independently selected from the group consisting of hydrogen, a linear or branched C1-C6 alkyl, a linear or branched C2-C6 alkenyl, a C3-C8 cycloalkyl, heterocyclyl, aryl and heteroaryl;
• X is selected from the group consisting of a bond, —O—, —S—, and —CR8R9, wherein R8 and R9 are independently selected from the group consisting of hydrogen and a linear or branched C1-C6 alkyl;
• m is 0, 1, 2, 3 or 4;
• and
• n is 0, 1, 2, 3, 4 or 5;
• including salts, optical isomers, geometrical isomers, enantiomers, diastereomers, and mixtures thereof.